Perfil neuro-hormonal de pacientes reumáticos com insuficiência aórtica crônica importante

Spina, Guilherme Sobreira; Tarasoutchi, Flávio; Sampaio, Roney Orismar; Vieira, Marcelo Luiz Campos; Laurindo, Francisco Rafael Martins; Grinberg, Max

doi:10.1590/s0066-782x2009000200012

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…As the LV becomes dilated and dysfunctional, there is an increase in inflammatory pathway gene expression,26 which is supported by clinical work in patients with severe chronic primary MR 71 , 75 and severe rheumatic aortic regurgitation. 76 Overall, there appears to be a biphasic elevation in the inflammatory response to mitral regurgitation, with early volume overload activating the expression of numerous inflammatory pathways, and decompensation triggering a second inflammatory response ( Fig. 3 ).…”

Section: Chronic Primary Mr Triggers An Inflammatory Responsementioning

confidence: 98%

Left ventricular remodelling in chronic primary mitral regurgitation: implications for medical therapy

McCutcheon¹,

Manga²

2018

CVJA

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SummarySurgical repair or replacement of the mitral valve is currently the only recommended therapy for severe primary mitral regurgitation. The chronic elevation of wall stress caused by the resulting volume overload leads to structural remodelling of the muscular, vascular and extracellular matrix components of the myocardium. These changes are initially compensatory but in the long term have detrimental effects, which ultimately result in heart failure. Understanding the changes that occur in the myocardium due to volume overload at the molecular and cellular level may lead to medical interventions, which potentially could delay or prevent the adverse left ventricular remodelling associated with primary mitral regurgitation. The pathophysiological changes involved in left ventricular remodelling in response to chronic primary mitral regurgitation and the evidence for potential medical therapy, in particular beta–adrenergic blockers, are the focus of this review.

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Section: Chronic Primary Mr Triggers An Inflammatory Responsementioning

confidence: 98%

Left ventricular remodelling in chronic primary mitral regurgitation: implications for medical therapy

McCutcheon¹,

Manga²

2018

CVJA

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“…Another study has also shown that NT–pro-BNP and BNP are associated with symptoms and left ventricular function in Aol. Spina et al 51 evaluated prospectively 89 young patients with Aol of rheumatic etiology and demonstrated that BNP had the same ability to predict the occurrence of symptoms and requirement of valve replacement when compared with ventricular diameters evaluated by echocardiography during a follow-up of 8 years.…”

Section: Biomarkers In Valvular Diseasementioning

confidence: 99%

Biomarkers in Cardiology - Part 2: In Coronary Heart Disease, Valve Disease and Special Situations

2015

Arquivos Brasileiros De Cardiologia

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Cardiovascular diseases are the main causes of mortality and morbidity in Brazil. Their primary and secondary preventions are a priority for the health system and require multiple approaches for increased effectiveness. Biomarkers are tools used to identify with greater accuracy high-risk individuals, establish a faster diagnosis, guide treatment, and determine prognosis. This review aims to highlight the importance of biomarkers in clinical cardiology practice and raise relevant points regarding their application and perspectives for the next few years. This document was divided into two parts. This second part addresses the application of biomarkers in coronary heart disease, valvular diseases, cardio-oncology, pulmonary embolism, and cardiorenal syndrome.

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Correlation between Serum Markers of Adverse Left Ventricular Remodelling and Gene Expression Levels Measured in the Myocardial Tissue of Patients with Chronic Primary Mitral Regurgitation

McCutcheon¹,

Dickens²,

Pelt³

et al. 2020

Wits Journal of Clinical Medicine

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Telephone number: +32 (0)16 34 15 33, Fax number: +32 (0) 16 32 15 13, keir.mccutcheon@uzleuven.be ABSTRACT Background: Chronic primary mitral regurgitation (CPMR) is characterized by progressive myocardial hypertrophy, fibrosis and dilatation. Although molecular markers of adverse left ventricular (LV) remodelling have been identified in the progression from compensated to decompensated heart failure in these patients, serum markers that could guide the optimal timing of intervention in these patients are still needed. Here we describe the correlation between the levels of expression of several genes important in adverse LV remodelling in CPMR and the serum levels of these markers. Methods:We performed echocardiography, cardiac catheterization, endomyocardial biopsy (EMB) and serum analysis in patients with severe CPMR during the preoperative workup for mitral valve surgery. Serum levels of N-terminal-pro hormone B-type natriuretic peptide, suppression of tumourigenicity 2, tumour necrosis factor a, Interleukin 6, FS-7-associated surface antigen (FAS), FAS ligand, matrix metalloproteinase (MMP)-1, MMP-2, MMP-9, tissue inhibitor of matrix metalloproteinases (TIMP)-1 and TIMP-4 were determined using commercially available enzyme-linked immunosorbent assays. Myocardial levels of expression of the genes encoding these proteins were determined by multiplex gene expression analysis.Results: Serum and EMBs were obtained from 12 patients with CPMR at the time of preoperative cardiac catheterization. Overall, there was no significant correlation between the serum levels and gene expression levels for the markers evaluated in this study. A non-significant inverse correlation between serum MMP-2 and myocardial MMP-2 was noted (r = −0.343, P = 0.263). Conclusion:We found a poor correlation between the myocardial gene expression levels of several markers of adverse LV remodelling in patients with CPMR and the serum levels of these markers sampled at the same time.

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Perfil neuro-hormonal de pacientes reumáticos com insuficiência aórtica crônica importante

Abstract: SummaryBackground: Neurohormones are involved in the physiopathology of heart failure, but little is known about its behavior in significant chronic aortic regurgitation (AR). We aimed at analyzing the behavior of these mediators in AF.

Cited by 3 publications

References 29 publications

Left ventricular remodelling in chronic primary mitral regurgitation: implications for medical therapy

Left ventricular remodelling in chronic primary mitral regurgitation: implications for medical therapy

Biomarkers in Cardiology - Part 2: In Coronary Heart Disease, Valve Disease and Special Situations

Correlation between Serum Markers of Adverse Left Ventricular Remodelling and Gene Expression Levels Measured in the Myocardial Tissue of Patients with Chronic Primary Mitral Regurgitation

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