Perfiles de resistencia y factores de riesgo de microorganismos resistentes en bacteriemia de origen abdominal

Jaramago, J. Martín; Ibáñez, R. Armero; Miñana, Juan José Camarena; Suárez-Varela, M. Morales

doi:10.1016/j.redar.2017.03.007

Cited by 1 publication

(1 citation statement)

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“…Persistent high rates of resistance at our setting could be accounted for by increasingly empirical use of antibiotics; in most cases imprudent use of antibiotics. As observed in our study, antibiotic use before blood culture was an increased risk for isolation of MDR bacteria, similar to previous literature [22]. However, one weakness of this study is its restriction on current hospital use of antibiotics to assess risk factors for MDR bacteria.…”

Section: Plos Onesupporting

confidence: 89%

Multi-drug resistant bacteria predict mortality in bloodstream infection in a tertiary setting in Tanzania

et al. 2020

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BackgroundBloodstream infections (BSI) are serious and life-threatening, associated with high mortality and morbidity. In resource-limited settings, there is a paucity of data on predictors of outcome in patients with BSI. This study aimed at examining the predictors of mortality in patients with BSI as well as bacteria causing BSI. Methods and materialsThis was a cross-sectional study conducted at Muhimbili National Hospital between April and May 2018. Blood culture results from all inpatients at the clinical microbiology laboratory were recorded and clinical information was retrieved retrospectively from the files. Bacteria from positive blood culture were identified and antimicrobial susceptibility was performed. ResultsThe overall prevalence of BSI was, 46/402 (11.4% 95% CI 8.6-15), with a case fatality rate of 37%. There was a significantly high rate of BSI in patients who had died (19.5%) compared to those who survived (9.2%) p = 0.008. Gram-negative bacteria (74%) were the common cause of BSI, with a predominance of Enterobacteriaceae ( 22), followed by Pseudomonas aeruginosa (11). The majority of bacteria (70.5%) isolated from patients with BSI were Multi-drug resistant (MDR). Forty-six percent of Pseudomonas aeruginosa were resistant to meropenem while 68% (15/22) of Enterobacteriaceae were extended-spectrum β lactamase producers. Carbapenemase production was detected in 27% (3/11) of Pseudomonas aeruginosa and one Proteus mirabilis. Forty percent of Staphylococcus aureus were methicillin-resistant Staphylococcus aureus. Positive blood culture (aOR 2.24, 95%CI 1.12-4.47, p 0.02) and admission to the intensive care unit (aOR 3.88, 95%CI 1.60-9.41, p = 0.003) were independent factors for mortality in suspected BSI. Isolation of MDR bacteria was an independent predictor for mortality in confirmed BSI (aOR 15.62, 95%CI 1.24-161.38, p = 0.02).

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Section: Plos Onesupporting

confidence: 89%