Perflubron as a gastrointestinal MR imaging contrast agent in the pediatric population

Bisset, George S.; Emery, Kathleen H.; Meza, Manuel P.; Rollins, Nancy; Don, Steven; Shorr, Jolene

doi:10.1007/bf01387316

Cited by 14 publications

(9 citation statements)

References 22 publications

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“…For MRI, the multi-resonance spectrum requires extensive editing. PFOB has been tested in clinical trials [276,277] and recently images were shown in mice based on perfluorononane [278].…”

Section: Gi Imagingmentioning

confidence: 99%

“…Traditional barium meals provide contrast in CT, and virtual colonoscopy is competing with traditional fiber optic probes [273]. MR procedures have lagged behind CT, but several potential contrast agents have been presented, ranging from paramagnetic zeolite formulations [274] and ferric ammonium citrate [275] to PFC emulsions [276]. Emulsions of perflubron (PFOB) have been applied to multiple applications and are popular in ultrasound [178,179].…”

Section: Gi Imagingmentioning

confidence: 99%

See 1 more Smart Citation

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Jian¹,

Kodibagkar²,

Cui³

et al. 2005

CMC

230

185

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The fluorine atom provides an exciting tool for diverse spectroscopic and imaging applications using Magnetic Resonance. The organic chemistry of fluorine is widely established and it can provide a stable moiety for interrogating many aspects of physiology and pharmacology in vivo. Strong NMR signal, minimal background signal and exquisite sensitivity to changes in the microenvironment have been exploited to design and apply diverse reporter molecules. Classes of agents are presented to investigate gene activity, pH, metal ion concentrations (e.g., Ca(2+), Mg(2+), Na(+)), oxygen tension, hypoxia, vascular flow and vascular volume. In addition to interrogating speciality reporter molecules, (19)F NMR may be used to trace the fate of fluorinated drugs, such as chemotherapeutics (e.g., 5-fluorouracil, gemcitabine), anesthetics (e.g., isoflurane, methoxyflurane) and neuroleptics. NMR can provide useful information through multiple parameters, including chemical shift, scalar coupling, chemical exchange and relaxation processes (R1 and R2). Indeed, the large chemical shift range (approximately 300 ppm) can allow multiple agents to be examined, simultaneously, using NMR spectroscopy or chemical shift selective imaging.

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“…For MRI, the multi-resonance spectrum requires extensive editing. PFOB has been tested in clinical trials [276,277] and recently images were shown in mice based on perfluorononane [278].…”

Section: Gi Imagingmentioning

confidence: 99%

Section: Gi Imagingmentioning

confidence: 99%

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Jian¹,

Kodibagkar²,

Cui³

et al. 2005

CMC

230

185

View full text Add to dashboard Cite

show abstract

“…Traditional barium meals provide contrast in CT, and virtual colonoscopy is competing with traditional fiber optic probes [388]. MR procedures have lagged behind CT, but several potential contrast agents have been presented, ranging from paramagnetic zeolite formulations [389] and ferric ammonium citrate [390] to PFC emulsions [391,392] and recently images were shown in mice based on perfluorononane [69].…”

Section: Passive Reporter Moleculesmentioning

confidence: 99%

VatuximabTM: Optimizing Therapeutic Strategies for Prostate Cancer Based on Dynamic MR Tumor Oximetry

Mason¹

2007

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS.

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“…Traditional barium meals provide contrast in CT, 4.4 Blood Flow and virtual colonoscopy is competing with traditional fiber optic probes [273]. MR procedures have lagged behind CT, Fluorinated gases (e.g., FC-23 (Tri-fluoromethane) and but several potential contrast agents have been presented, FC-22 (chlorofluoromethane)) have been used to examine ranging from paramagnetic zeolite formulations [274] and cerebral blood flow based on inflow and outflow kinetics, ferric ammonium citrate [275] to PFC emulsions [276].…”

Section: Hypoxia Hypoxic Fraction and In Vivo Nitroreductase Activitimentioning

confidence: 99%

“…For MRI, the multi-resonance spectrum requires extensive editing. PFOB has been tested in clinical trials [276,277] and recently images were shown in mice based on 5. METABOLISM AND DRUG UPTAKE perfluorononane [278].…”

Section: Hypoxia Hypoxic Fraction and In Vivo Nitroreductase Activitimentioning

confidence: 99%

Breast Cancer Gene Therapy: Development of Novel Non-Invasive Magnetic Resonance Assay to Optimize Efficacy

Mason¹

2005

View full text Add to dashboard Cite

Public reporting burden for this collection of information Is estimated to average 1 hour per response, Including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, ABSTRACT (Maximum 200 Words)Gene therapy holds great promise for treatment of breast cancer. In particular, clinical trials are underway to apply therapeutic genes related to pro-drug activation or to modulate the activity of oncogenes by blocking promoter sites. However, there are major problems in terms of assessing the delivery to target tissue, assessing the uniformity (versus heterogeneity) of biodistribution and determining whether the genes are expressed. We propose to design, evaluate and apply a novel approach to gene activity detection-specifically, using fluorinated substrates of P-galactosidase to reveal gene activity. Our prototype molecule PFONPG (para-fluoro-ortho-nitro-phenyl P3-D-galactopyranoside) is a direct analog of the traditional "yellow' biochemical indicator ONPG (ortho-nitro-phenyl 3-D-galactopyranoside). This shows useful MR characteristics, sensitivity to enzyme activity and ability to enter cells. We will synthesize analogs of this prototype to optimize MR and biological characteristics and explore the feasibility of tailoring the reporter to specific applications, e.g., exploiting P-gal activity to deliver specific physiological reporter molecules such as pH and potentially specific cytotoxic agents. The agents will be rigorously tested in solution, applied to cultured breast cancer cells and ultimately used to examine P-gal activity in vivo in transfected breast tumors in mice and rats. SUBJECT TERMS NUMBER OF PAGESGene therapy, fluorine NMR, P-galactosidase, pH 127 IntroductionGene therapy holds great promise for treatment of breast cancer (1, 2). In particular, clinical trials are underway to apply therapeutic genes related to pro-drug activation or modulation of the activity of oncogenes by blocking promoter sites. However, there are major problems in terms of assessing the delivery to target tissue, assessing the uniformity (versus heterogeneity) of biodistribution and determining whether the genes are expressed. We propose to design, evaluate and apply a novel approach to gene activity detection-specifically, using fluorinated substrates of P3-galactosidase to reveal gene activity. Our prototype molecule PFONPG (para-fluoro-ortho-nitro-phenyl [3-D-galactopyranoside) is a direct analog of the traditional "yellow' biochemical indicator ONPG (ortho-nitro-phenyl 13-D-galactopyranoside).This shows useful MR characteristics, sensitivity to enzyme activity ...

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Perflubron as a gastrointestinal MR imaging contrast agent in the pediatric population

Abstract: Perflubron is a relatively safe and effective gastrointestinal MR contrast agent in the pediatric population.

Cited by 14 publications

References 22 publications

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

VatuximabTM: Optimizing Therapeutic Strategies for Prostate Cancer Based on Dynamic MR Tumor Oximetry

Breast Cancer Gene Therapy: Development of Novel Non-Invasive Magnetic Resonance Assay to Optimize Efficacy

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