Perfluoroalkyl substances in cord blood and attention deficit/hyperactivity disorder symptoms in seven-year-old children

Lien, Guang-Wen; Huang, Chin‐Cheng; Shiu, Jia-Shian; Chen, Mei-Huei; Hsieh, Wu‐Shiun; Guo, Yang; Chen, Pau‐Chung

doi:10.1016/j.chemosphere.2016.04.102

Cited by 84 publications

(52 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liew, et al [ 42 ] reported potential positive associations between ADHD and maternal plasma PFOA in the Danish National Birth Cohort, though some associations were only observed when examining quartiles of exposure. In a cohort created by combining data from the Taiwan birth panel study and the Taiwan early-life cohort, Lien, et al [ 43 ] found cord blood PFNA concentrations to be associated with inattention, impulsivity/hyperactivity, and oppositional defiant disorder as measured by the Swanson, Nolan, and Pelham IV scale but not neurobehavioral symptoms measured by the Child Behavior Checklist (CBC) or the Strengths and Difficulties Questionnaire. They also found only null associations between PFOA, PFOS, and PFNA and neurobehavioral symptoms of ADHD [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

“…In a cohort created by combining data from the Taiwan birth panel study and the Taiwan early-life cohort, Lien, et al [ 43 ] found cord blood PFNA concentrations to be associated with inattention, impulsivity/hyperactivity, and oppositional defiant disorder as measured by the Swanson, Nolan, and Pelham IV scale but not neurobehavioral symptoms measured by the Child Behavior Checklist (CBC) or the Strengths and Difficulties Questionnaire. They also found only null associations between PFOA, PFOS, and PFNA and neurobehavioral symptoms of ADHD [ 43 ]. Quaak, et al [ 44 ], using the Dutch Linking Maternal Nutrition to Child Health cohort (PFAS measured in cord blood), found higher PFOA tertiles associated with potential decreases in externalizing behavior using the CBC, but no associations with the ADHD scale, and no associations with PFOS concentrations; however, they did observe potential negative associations between summed PFAS and both externalizing behavior and ADHD.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Exposure to Perfluorinated Alkyl Substances and Health Outcomes in Children: A Systematic Review of the Epidemiologic Literature

Rappazzo

Coffman

Hines

2017

IJERPH

295

163

View full text Add to dashboard Cite

Perfluoroalkyl substances (PFAS), chemicals used to make products stain and stick resistant, have been linked to health effects in adults and adverse birth outcomes. A growing body of literature also addresses health effects in children exposed to PFAS. This review summarizes the epidemiologic evidence for relationships between prenatal and/or childhood exposure to PFAS and health outcomes in children as well as to provide a risk of bias analysis of the literature. A systematic review was performed by searching PubMed for studies on PFAS and child health outcomes. We identified 64 studies for inclusion and performed risk of bias analysis on those studies. We determined that risk of bias across studies was low to moderate. Six categories of health outcomes emerged. These were: immunity/infection/asthma, cardio-metabolic, neurodevelopmental/attention, thyroid, renal, and puberty onset. While there are a limited number of studies for any one particular health outcome, there is evidence for positive associations between PFAS and dyslipidemia, immunity (including vaccine response and asthma), renal function, and age at menarche. One finding of note is that while PFASs are mixtures of multiple compounds few studies examine them as such, therefore the role of these compounds as complex mixtures remains largely unknown.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Exposure to Perfluorinated Alkyl Substances and Health Outcomes in Children: A Systematic Review of the Epidemiologic Literature

Rappazzo

Coffman

Hines

2017

IJERPH

295

163

View full text Add to dashboard Cite

show abstract

“…Three cross-sectional studies [83, 84, 85], including one using NHANES, reported higher serum levels of some PFASs to be positively correlated with impulsivity and ADHD in school-aged children. However, these findings were not corroborated in most longitudinal studies that evaluated prenatal PFASs exposures and an ADHD diagnosis [76, 81, 73], or parent- or teacher-reported ADHD symptoms or behavioral scores [72, 74•, 77] during childhood. Only in the INUENDO cohort that combined data from Greenland, Kharkiv (Ukraine) and Warsaw (Poland) found that prenatal exposure to PFOS and PFOA had a small to moderate size effect on hyperactive behavior in children ages 5–9 years; estimated effects were strongest in Greenland where exposure contrasts were the largest among these countries [75].…”

Section: Neurodevelopmental Effectsmentioning

confidence: 87%

Developmental Exposures to Perfluoroalkyl Substances (PFASs): An Update of Associated Health Outcomes

Liew

Goudarzi

Oulhote

2018

Curr Envir Health Rpt

182

View full text Add to dashboard Cite

PFASs are persistent organic pollutants that have been widely produced and used in a range of commercial products since the 1950s. Human exposures to PFASs are nearly ubiquitous globally, but studies that addressed potential health effects of PFASs have only begun to accumulate in recent years. Animal studies suggest adverse effects resulting from developmental encompasses prenatal exposures to PFASs. In humans, the developing fetus is exposed to PFASs via active or passive placenta transfer, while newborns might be exposed via breastfeeding or PFAS in the home environment. Overall, epidemiological findings are consistent and suggest possible associations with fetal and postnatal growth and immune function, while the findings on neurodevelopmental endpoints to date are rather inconclusive. Methodological challenges and future directions for PFASs-focused research are discussed.

show abstract

“…The details of both cohorts were described elsewhere [19]. Briefly, during 2004 and 2005, the TBPS recruited 486 births from one medical center, one regional hospital, and two clinics in the Taipei metropolitan area.…”

Section: Methodsmentioning

confidence: 99%

Effects of Gender on the Association of Urinary Phthalate Metabolites with Thyroid Hormones in Children: A Prospective Cohort Study in Taiwan

Weng

Chen

Lien

et al. 2017

IJERPH

Self Cite

View full text Add to dashboard Cite

Phthalates are considered endocrine disruptors. Our study assessed the gender-specific effects of phthalate exposure on thyroid function in children. In total, 189 Taiwanese children were enrolled in the study. One-spot urine and blood samples were collected for analyzing 12 phthalate metabolites in urine and thyroid hormones. The association between urinary phthalate metabolites and serum thyroid hormones was determined using a generalized linear model with a log link function; the children were categorized into groups for analysis according to the 33rd and 66th percentiles. The data were stratified according to gender and adjusted for a priori defined covariates. In girls, a positive association existed between urinary di-2-ethylhexyl phthalate (DEHP) metabolites (mono-(2-ethylhexyl) phthalate, mono-(2-ethyl-5-oxohexyl) phthalate, and mono-(2-ethyl-5-hydroxyhexyl) phthalate) and free thyroxine (T4). In boys, urinary dibutyl phthalate (DBP) metabolites (mono-i-butyl phthalate and mono-n-butyl phthalate) were positively associated with free triiodothyronine (T3). After categorizing each exposure into three groups, urinary DEHP metabolites were positively associated with free T3 levels in boys. Our results suggested that DEHP is associated with free T4 in girls and that DBP is associated with free T3 in boys. Higher DEHP metabolite concentrations exerted larger effects on free T3 in boys. These results reveal the gender-specific relationships between phthalate metabolites and thyroid hormones.

show abstract

Perfluoroalkyl substances in cord blood and attention deficit/hyperactivity disorder symptoms in seven-year-old children

Cited by 84 publications

References 46 publications

Exposure to Perfluorinated Alkyl Substances and Health Outcomes in Children: A Systematic Review of the Epidemiologic Literature

Exposure to Perfluorinated Alkyl Substances and Health Outcomes in Children: A Systematic Review of the Epidemiologic Literature

Developmental Exposures to Perfluoroalkyl Substances (PFASs): An Update of Associated Health Outcomes

Effects of Gender on the Association of Urinary Phthalate Metabolites with Thyroid Hormones in Children: A Prospective Cohort Study in Taiwan

Contact Info

Product

Resources

About