Perfluoroalkylated poly(oxyethylene) thiols: Synthesis, adsorption dynamics and surface activity at the air/water interface, and bubble stabilization behaviour

Polavarapu, Prasad L.; Krafft, Marie Pierre

doi:10.1016/j.jfluchem.2014.10.020

Cited by 8 publications

(4 citation statements)

References 47 publications

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“…We evaluated the key properties of the prepared solutions, such as interfacial tension at the air–liquid boundary, density, and viscosity (Table S1). The interfacial tension values of all solutions were in an adequate range for MB formation (between 28 and 42 mN/m) since higher values would promote the formation of micelles and emulsions. ,,− All surfactant solutions had very similar density values, which guaranteed that once the MB had formed, the same centrifugation conditions could be applied to all samples. Regarding viscosity, Triton X solutions were slightly more viscous than the Tween solutions.…”

Section: Resultsmentioning

confidence: 99%

Engineering the Acoustic Response and Drug Loading Capacity of PBCA-Based Polymeric Microbubbles with Surfactants

et al. 2022

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Gas-filled microbubbles (MB) are routinely used in the clinic as ultrasound contrast agents. MB are also increasingly explored as drug delivery vehicles based on their ultrasound stimuli-responsiveness and well-established shell functionalization routes. Broadening the range of MB properties can enhance their performance in both imaging and drug delivery applications. This can be promoted by systematically varying the reagents used in the synthesis of MB, which in the case of polymeric MB include surfactants. We therefore set out to study the effect of key surfactant characteristics, such as the chemical structure, molecular weight, and hydrophilic–lipophilic balance on the formation of poly(butyl cyanoacrylate) (PBCA) MB, as well as on their properties, including shell thickness, drug loading capacity, ultrasound contrast, and acoustic stability. Two different surfactant families (i.e., Triton X and Tween) were employed, which show opposite molecular weight vs hydrophilic–lipophilic balance trends. For both surfactant types, we found that the shell thickness of PBCA MB increased with higher-molecular-weight surfactants and that the resulting MB with thicker shells showed higher drug loading capacities and acoustic stability. Furthermore, the higher proportion of smaller polymer chains of the Triton X-based MB (as compared to those of the Tween-based ones) resulted in lower polymer entanglement, improving drug loading capacity and ultrasound contrast response. These findings open up new avenues to fine-tune the shell properties of polymer-based MB for enhanced ultrasound imaging and drug delivery applications.

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Section: Resultsmentioning

confidence: 99%

Engineering the Acoustic Response and Drug Loading Capacity of PBCA-Based Polymeric Microbubbles with Surfactants

et al. 2022

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“…The interfacial tension can be reduced by increasing the chain length of the encapsulating shell of bubbles which can extend stability of bubbles. 56,57 The results show the high stability and specicity of PFH bubbles from nanoparticles at physiological conditions and the great potential of these nanoparticles as in vivo contrast agents for tumor monitoring during therapy.…”

Section: Nonlinear Ultrasound (Nl Us) Imaging Of Pfh Bubblesmentioning

confidence: 92%

Laser activatable perfluorocarbon bubbles for imaging and therapy through enhanced absorption from coupled silica coated gold nanoparticles

et al. 2021

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“…Some primary factors influencing the high stability of PFH bubbles is the type of stabilizer used (in this case Zonyl FSP fluorosurfactant) in lowering interfacial tension, the lower solubility and diffusivity of perfluorohexane (compared to other gases used to make bubbles) (Cokkinos, 2014) which increases the dissolution time before PFH bubbles undergo collapse. The interfacial tension can be reduced by increasing the chain length of the encapsulating shell of bubbles which can extend stability of bubbles (Polavarapu & Krafft, 2015;Szijjarto, Rossi, Waton, & Krafft, 2012). The results show the high stability and specificity of PFH bubbles from nanoparticles at physiological conditions and the great potential of these nanoparticles as in vivo contrast agents for tumor monitoring during therapy.…”

Section: Introductionmentioning

confidence: 93%

Multifunctional perfluorocarbon nanoemulsions for cancer therapy and imaging

Fernandes

Wang

et al. 2015

SPIE Proceedings

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Perfluoroalkylated poly(oxyethylene) thiols: Synthesis, adsorption dynamics and surface activity at the air/water interface, and bubble stabilization behaviour

Cited by 8 publications

References 47 publications

Engineering the Acoustic Response and Drug Loading Capacity of PBCA-Based Polymeric Microbubbles with Surfactants

Engineering the Acoustic Response and Drug Loading Capacity of PBCA-Based Polymeric Microbubbles with Surfactants

Laser activatable perfluorocarbon bubbles for imaging and therapy through enhanced absorption from coupled silica coated gold nanoparticles

Multifunctional perfluorocarbon nanoemulsions for cancer therapy and imaging

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