Perfluorohexane‐Encapsulated Mesoporous Silica Nanocapsules as Enhancement Agents for Highly Efficient High Intensity Focused Ultrasound (HIFU)

Wang, Xia; Chen, Hangrong; Chen, Yu; Ma, Ming; Zhang, Kun; Li, Faqi; Zheng, Yuanyi; Zeng, Deping; Wang, Qi; Shi, Jianlin

doi:10.1002/adma.201104033

Cited by 219 publications

(208 citation statements)

References 33 publications

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“…7c). This on-demand drug-release pattern is of practical importance because the focused ultrasound noninvasively penetrates to deep tumors [61][62][63]. As expected, HMCN-mediated DOX delivery significantly enhanced the therapeutic efficiency and sustainably inhibited tumor growth compared to free DOX (Fig.…”

Section: Mcbs For Controlled Delivery and Release Of Therapeutic Agentssupporting

confidence: 61%

Mesoporous carbon biomaterials

Chen

Shi

2015

Sci. China Mater.

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Nano-biotechnology provides highly efficient and versatile strategies to improve the diagnostic precision and therapeutic efficiency of serious diseases. The development of new biomaterial systems provides great opportunities for the successful clinical translation of nano-biotechnology for personalized biomedicine to benefit patients. As a new inorganic material system, mesoporous carbon biomaterials (

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Section: Mcbs For Controlled Delivery and Release Of Therapeutic Agentssupporting

confidence: 61%

Mesoporous carbon biomaterials

Chen

Shi

2015

Sci. China Mater.

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“…14,15 Notably, our groups recently fabricated PFC nanosystems capable of phase transition that successfully delivered to release drugs and affect gene expression, 16 facilitate multimodal imaging, 17,18 and increase the therapeutic efficiencies of high-intensity focused US (HIFU) and chemoembolization. 19 The liquid-gas phase transition of perfluorohexane (PFH, boiling point [BP] 58°C-60°C) can be triggered by hyperthermia under HIFU; however, this operation is risky and invasive and does not allow intraoperative imaging. 19 This study developed phase-changeable and folate receptor (FR)-targeted nanodroplets with a low BP (29°C) PFC (perfluoropentane, PFP) core (termed FA-NDs) for use as a novel US molecular probe that can pass through the capillary endothelium gaps of tumor blood vessels and actively target FR-positive tumor cells.…”

Section: Introductionmentioning

confidence: 99%

“…19 The liquid-gas phase transition of perfluorohexane (PFH, boiling point [BP] 58°C-60°C) can be triggered by hyperthermia under HIFU; however, this operation is risky and invasive and does not allow intraoperative imaging. 19 This study developed phase-changeable and folate receptor (FR)-targeted nanodroplets with a low BP (29°C) PFC (perfluoropentane, PFP) core (termed FA-NDs) for use as a novel US molecular probe that can pass through the capillary endothelium gaps of tumor blood vessels and actively target FR-positive tumor cells. Importantly, different from prior work to activate phase transition with HIFU, this is the first time PFC nanodroplet phase transition has been induced by low-intensity focused US (LIFU).…”

Section: Introductionmentioning

confidence: 99%

<div>Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging</div>

Liu¹,

Shang²,

Wang³

et al. 2017

IJN

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The commonly used ultrasound (US) molecular probes, such as targeted microbubbles and perfluorocarbon emulsions, present a number of inherent problems including the conflict between US visualization and particle penetration. This study describes the successful fabrication of phase changeable folate-targeted perfluoropentane nanodroplets (termed FA-NDs), a novel US molecular probe for tumor molecular imaging with US. Notably, these FA-NDs can be triggered by low-intensity focused US (LIFU) sonication, providing excellent US enhancement in B-mode and contrast-enhanced US mode in vitro. After intravenous administration into nude mice bearing SKOV3 ovarian carcinomas, 1,1′-dioctadecyl-3,3,3′,3′ -tetramethylindotricarbocya-nine iodide-labeled FA-NDs were found to accumulate in the tumor region. FA-NDs injection followed by LIFU sonication exhibited remarkable US contrast enhancement in the tumor region. In conclusion, combining our elaborately developed FA-NDs with LIFU sonication provides a potential protocol for US molecular imaging in folate receptor-overexpressing tumors.

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“…To further promote therapeutic efficacy, several HIFU synergistic agents (SAs), such as organic microbubbles, organic nanoemulsions and inorganic nanoparticles, have been successfully fabricated. These SAs increase the ultrasonic cavitation effect by changing the acoustic environment within the tumor thereby boosting energy deposition and enhancing the efficacy and safety of HIFU therapy [16][17][18]. Even so, organic contrast agents have the disadvantages of extremely large particle size and low biostability, which prevent them from permeating tumor tissues [19][20].…”

Section: Ivyspringmentioning

confidence: 99%

A Multifunctional Theranostic Nanoagent for Dual-Mode Image-Guided Hifu/Chemo- Synergistic Cancer Therapy

Zhang

Cai

2017

Ultrasound in Medicine & Biology

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High-intensity focused ultrasound (HIFU) is deemed to be a promising noninvasive therapeutic modality for cancers as well as non-neoplastic diseases. However, the accuracy of the technique in the diagnosis and treatment of tumors remains unsatisfactory. HIFU, when combined with multifunctional synergistic agents (SAs), has the potential to be of greater diagnostic and therapeutic efficacy. Here we describe a smart and multifunctional hollow mesoporous Prussian blue (HMPBs) theranostic nanoplatform, the hollow structure of which is capable of encapsulating doxorubicin (DOX) and perfluorohexane (HMPBs-DOX/PFH). In vitro and in vivo studies validated that HMPBs-DOX/PFH can be used as an amplifiable dual-mode imaging contrast agent, which can simultaneously enhance ultrasound (US) and photoacoustic (PA) imaging for guiding and monitoring tumor therapy. When exposed to HIFU, this versatile HMPBs-DOX/PFH agent could increase the cavitation effect and use lower HIFU intensity to achieve coagulative necrosis. Furthermore, it significantly accelerated the release of DOX thereby enhancing chemotherapeutic efficacy and avoiding systemic side effects of the drug. Such a novel theranostic nanoplatform is expected to integrate dual-mode guided imaging with greater therapeutic efficacy and fewer side effects and is very promising for the noninvasive synergistic tumor therapy.

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Perfluorohexane‐Encapsulated Mesoporous Silica Nanocapsules as Enhancement Agents for Highly Efficient High Intensity Focused Ultrasound (HIFU)

Cited by 219 publications

References 33 publications

Mesoporous carbon biomaterials

Mesoporous carbon biomaterials

<div>Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging</div>

A Multifunctional Theranostic Nanoagent for Dual-Mode Image-Guided Hifu/Chemo- Synergistic Cancer Therapy

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