Perfluorooctane sulfonate induces mitochondrial calcium overload and early hepatic insulin resistance via autophagy/detyrosinated alpha-tubulin-regulated IP3R2-VDAC1-MICU1 interaction

Dong, Zhanchen; Wang, Yunlong; Qiu, Tianming; Wu, Jialu; An, Yu; Shi, Xiaoxia; Sun, Xiance; Jiang, Liping; Liu, Xiaofang; Yang, Guang; Cao, Jun; Yao, Xiaofeng

doi:10.1016/j.scitotenv.2022.153933

Cited by 26 publications

(7 citation statements)

References 54 publications

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“…For the liver, PFOS induced LC3-II and LC3-II/I expression in L-02 cells in a concentration-dependent manner, stimulated autophagic flux, and decreased p62 expression [ 148 ]. It was also found that PFOS altered the post-translational modification of α-tubulin associated with autophagy in L-02 cells, but no changes in α-tubulin were found in the livers of PFOS-treated mice [ 149 ]. However, the mechanism is unclear and needs to be further explored.…”

Section: Signaling Pathways Associated With Hepatotoxic Damage Caused...mentioning

confidence: 99%

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Wang

Liu

Yan

et al. 2022

Toxics

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Perfluorooctane sulfonate (PFOS) is a persistent, widely present organic pollutant. PFOS can enter the human body through drinking water, ingestion of food, contact with utensils containing PFOS, and occupational exposure to PFOS, and can have adverse effects on human health. Increasing research shows that the liver is the major target of PFOS, and that PFOS can damage liver tissue and disrupt its function; however, the exact mechanisms remain unclear. In this study, we reviewed the adverse effects of PFOS on liver tissue and cells, as well as on liver function, to provide a reference for subsequent studies related to the toxicity of PFOS and liver injury caused by PFOS.

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Section: Signaling Pathways Associated With Hepatotoxic Damage Caused...mentioning

confidence: 99%

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Wang

Liu

Yan

et al. 2022

Toxics

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“…The frequent occurrence of high temperature heatwaves may not directly trigger drought, but when it occurs, high temperature heatwaves will cause the drought to develop more rapidly and with greater intensity [47]. On the other hand, drought also provides strong atmospheric circulation and underlying surface conditions for the generation of high temperatures and heatwaves [48,49], thus having a significant impact upon the socio-economic and ecological environment. In their recent work, Perkins-Kirkpatrick introduced accumulated heat and mean temperature anomalies of heatwave days into the assessment of global heatwaves, which quantitatively analyzed regional differences in terms of heatwave intensity [41].…”

Section: Discussionmentioning

confidence: 99%

Increased Compound Droughts and Heatwaves in a Double Pack in Central Asia

Wang

Chen

et al. 2022

Remote Sensing

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Compound droughts and heatwaves (CDHWs) are likely to cause more severe natural disasters than a single extreme event, and they have been exacerbated by rapid global warming. Based on high-resolution grid data, this study combines the daily-scale ERA5-Land dataset and the monthly-scale SPEI dataset with multiple indicators to analyze CDHWs. We calculated and analyzed the temporal and spatial modal distribution of CDHWs in Central Asia from 1981 to 2018, and in this paper, we discuss the sequence relationship between drought events, heatwave events, and CDHWs. The results show that the number of CDHWs in the study region have increased over time and expanded in terms of area, especially in eastern and southwestern Central Asia. The tsum (total frequency of CDHWs) was 0.5 times higher than the total heatwave frequency and it increased at a rate of 0.17/yr. The maximum duration of tmax (maximum duration of CDHWs in days) was 17 days. Furthermore, the occurrence rate of tmax was 96.67%, and the AH (CDHWs’ accumulated heat) had a rate of 97.78%, which, upon examination of the spatial trend pattern, accounted for the largest increase in terms of area. We also found that the TAH (CDHWs’ average temperature anomalies, SPEI < −0.5) shows obvious seasonality, with the increases in winter and spring being significantly greater than the increases in summer and autumn. The intensity of the CDHWs was stronger than that of a single extreme event, the temperature anomaly was higher than the average of 0.4–0.8 °C, and there was a north–south spatial pattern across the study region. In eastern and northwestern Central Asia, the AH and heatwaves (SPEI < −0.5) increased by 15–30 times per year on average. During the transition from the base period to the reference period, CDHWs increased by 25%, and the number of dry days prior to the CDHWs decreased by 7.35 days. The conclusion of our study can provide a theoretical basis for coping with climate change in arid zones.

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“…Furthermore, reduced mitochondrial Ca 2+ , resulting from the mutation and acute deletion of seipin, a protein modulating mitochondrial Ca 2+ by interacting with SERCA, 436,437 has been pointed out to impair tricarboxylic acid cycle cycles and subsequent reduction in citrate, 438 leading to the defects in lipid storage and lipogenesis. Similar to mitochondrial Ca 2+ deficiency, mitochondrial Ca 2+ overload caused by excessive MAM content has also been shown to induce IR and fat deposition in hepatocytes 439,440 . Meanwhile, in the skeletal muscle, MAM formation is also found to be augmented by obesity in a PDK4‐dependent way, thereby leading to increased mitochondrial Ca 2+ accumulation, mitochondrial dysfunction, ER stress, and consequent IR 434 …”

Section: Signaling Pathways In T2dmmentioning

confidence: 99%

“…Similar to mitochondrial Ca 2+ deficiency, mitochondrial Ca 2+ overload caused by excessive MAM content has also been shown to induce IR and fat deposition in hepatocytes. 439,440 Meanwhile, in the skeletal muscle, MAM formation is also found to be augmented by obesity in a PDK4-dependent way, thereby leading to increased mitochondrial Ca 2+ accumulation, mitochondrial dysfunction, ER stress, and consequent IR. 434 Furthermore, other regulators and signaling pathways responsible for whole-cellular Ca 2+ homeostasis also play critical roles in regulating peripheral IR progression.…”

Section: Ca 2+ Signalsmentioning

confidence: 99%

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

Cao

Tian

Zhang

et al. 2023

MedComm

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Type 2 diabetes mellitus (T2DM) represents one of the fastest growing epidemic metabolic disorders worldwide and is a strong contributor for a broad range of comorbidities, including vascular, visual, neurological, kidney, and liver diseases. Moreover, recent data suggest a mutual interplay between T2DM and Corona Virus Disease 2019 (COVID‐19). T2DM is characterized by insulin resistance (IR) and pancreatic β cell dysfunction. Pioneering discoveries throughout the past few decades have established notable links between signaling pathways and T2DM pathogenesis and therapy. Importantly, a number of signaling pathways substantially control the advancement of core pathological changes in T2DM, including IR and β cell dysfunction, as well as additional pathogenic disturbances. Accordingly, an improved understanding of these signaling pathways sheds light on tractable targets and strategies for developing and repurposing critical therapies to treat T2DM and its complications. In this review, we provide a brief overview of the history of T2DM and signaling pathways, and offer a systematic update on the role and mechanism of key signaling pathways underlying the onset, development, and progression of T2DM. In this content, we also summarize current therapeutic drugs/agents associated with signaling pathways for the treatment of T2DM and its complications, and discuss some implications and directions to the future of this field.

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Perfluorooctane sulfonate induces mitochondrial calcium overload and early hepatic insulin resistance via autophagy/detyrosinated alpha-tubulin-regulated IP3R2-VDAC1-MICU1 interaction

Cited by 26 publications

References 54 publications

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Increased Compound Droughts and Heatwaves in a Double Pack in Central Asia

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

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