Perfluorooctane Sulphonic Acid (PFOS), Its Salts, and Perfluorooctane Sulphonyl Fluoride (PFOS-F)

Kumari, Kanchan; Shahbaz, Md

doi:10.1007/978-3-031-50996-4_20

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Cited by 2 publications

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Per- and poly fluorinated substances: The poison in our waters – A call to action for India's aquatic future

Puttamreddy,

Ramesh,

Nippatlapalli

et al. 2025

Journal of Environmental Chemical Engineering

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Per- and poly fluorinated substances: The poison in our waters – A call to action for India's aquatic future

Puttamreddy,

Ramesh,

Nippatlapalli

et al. 2025

Journal of Environmental Chemical Engineering

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Dose-Dependent Effects of PFOS on Thyroid Hormone-Driven Neurodevelopment and Metamorphic-like change inXenopus laevislarvae

Zirkle,

Myers,

Thompson

2024

Preprint

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PFOS is a banned stain repellent that is a type of PFAS, a category of chemicals commonly referred to as "forever chemicals." These substances are known for their bioaccumulative nature and their resistance to degradation in the environment. Emerging data indicates that PFOS may disrupt thyroid hormone (TH) signaling, which plays a pivotal role in healthy vertebrate development, particularly neural development. Our study investigates whether PFOS interferes with TH-dependent developmental changes, with focus on the developing brain, in Xenopus laevis larvae. To assess this, we exposed five-day old larvae to varying concentrations of PFOS (25 ug/L, 2.5 ug/L, and 250 ng/L). Additionally, some larvae were exposed to either 15 ug/L or 1.5 ug/L of thyroxine to evaluate PFOS's potential interference with TH-dependent developmental mechanisms. After four days, we euthanized larvae and examined body length and hind limb size, dissected out brains and performed immunostaining for markers of neuronal proliferation and apoptosis. We found that PFOS significantly impeded overall body growth in a dose-dependent manner, irrespective of TH status. Moreover, PFOS impaired TH-stimulated hind limb development. In the brain, PFOS had no effect on proliferation but hindered TH-stimulated growth of the optic tectum. Last, PFOS increased apoptosis in the optic tectum, indicative of cytotoxicity. These findings suggest that PFOS may have the capacity to disrupt TH-dependent mechanisms involved in brain development. The observed pattern of change also suggests that its impact is cytotoxic and may not stem solely from a canonical endocrine disruption mechanism.

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Perfluorooctane Sulphonic Acid (PFOS), Its Salts, and Perfluorooctane Sulphonyl Fluoride (PFOS-F)

Cited by 2 publications

References 45 publications

Per- and poly fluorinated substances: The poison in our waters – A call to action for India's aquatic future

Per- and poly fluorinated substances: The poison in our waters – A call to action for India's aquatic future

Dose-Dependent Effects of PFOS on Thyroid Hormone-Driven Neurodevelopment and Metamorphic-like change inXenopus laevislarvae

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