Perfluorooctanesulfonate and related fluorochemicals in biological samples from the north coast of Colombia

Olívero-Verbel, Jesús; Lin, Tao; Johnson‐Restrepo, Boris; Güette-Fernández, Jorge; Baldiris-Avila, Rosa; O'Byrne-Hoyos, Indira; Kannan, Kurunthachalam

doi:10.1016/j.envpol.2005.09.022

Cited by 85 publications

(47 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These brain levels were comparable to those found in recent studies on the brain of harbor porpoises (24 ng/g wet wt) off the coast of Ukraine [21] and the brain of harbor seals from the German Bight (99 ng/g wet wt) [17]. In the brains of avian species (glaucous gulls, pelicans) [22,24], PFOS concentrations have been found to be lower (<5 and 3.5 ng/g wet wt, respectively) than those in the current polar bear brain samples (Fig. 5).…”

Section: Comparison With Pfcas and Pfsas In The Brains Of Other Studisupporting

confidence: 87%

“…Harbor porpoise (1997-1998) [21] Harbor seal (2007) [17] Glaucous gull (2004) [24] Brown pelican (2004) [22] Fig been reported for polar bear liver, where the major PFCA was PFNA (C 9 ) [37,38]. This is a more pronounced shift than what was found in harbor seals [17], where there was a slight shift from C 9 being dominant in the liver to C 10 being dominant in the brain.…”

Section: Comparison With Pfcas and Pfsas In The Brains Of Other Studimentioning

confidence: 83%

“…Although concentrations of PFOS and other PFCAs and PFSAs in the liver of polar bears have been shown to be extremely high [3], no studies have investigated levels of any PFASs in other tissues or body compartments, including the brain or among brain regions [17,[19][20][21][22][23][24]. In the brain, PFOS has been detected following laboratory animal exposure [25], demonstrating its ability to cross the BBB.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in East Greenland polar bears (Ursus maritimus)

Greaves

Letcher

Sonne

et al. 2013

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Abstract-The present study investigated the comparative accumulation of perfluoroalkyl acids (PFAAs) in eight brain regions of polar bears (Ursus maritimus, n ¼ 19) collected in 2006 from Scoresby Sound, East Greenland. The PFAAs studied were perfluoroalkyl carboxylates (PFCAs, C 6 -C 15 chain lengths) and sulfonates (C 4 , C 6 , C 8 , and C 10 chain lengths) as well as selected precursors including perfluorooctane sulfonamide. On a wet-weight basis, blood-brain barrier transport of PFAAs occurred for all brain regions, although inner regions of the brain closer to incoming blood flow (pons/medulla, thalamus, and hypothalamus) contained consistently higher PFAA concentrations compared to outer brain regions (cerebellum, striatum, and frontal, occipital, and temporal cortices). For pons/medulla, thalamus, and hypothalamus, the most concentrated PFAAs were perfluorooctane sulfonate (PFOS), ranging from 47 to 58 ng/g wet weight, and perfluorotridecanoic acid, ranging from 43 to 49 ng/g wet weight. However, PFOS and the longer-chain PFCAs (C 10 -C 15 ) were significantly (p < 0.002) positively correlated with lipid content for all brain regions. Lipid-normalized PFOS and PFCA (C 10 -C 15 ) concentrations were not significantly (p > 0.05) different among brain regions. The burden of the sum of PFCAs, perfluoroalkyl sulfonates, and perfluorooctane sulfonamide in the brain (average mass, 392 g) was estimated to be 46 mg. The present study demonstrates that both PFCAs and perfluoroalkyl sulfonates cross the blood-brain barrier in polar bears and that wet-weight concentrations are brain region-specific. Environ. Toxicol. Chem. 2013;32:713-722. # 2012 SETAC

show abstract

Section: Comparison With Pfcas and Pfsas In The Brains Of Other Studisupporting

confidence: 87%

Section: Comparison With Pfcas and Pfsas In The Brains Of Other Studimentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in East Greenland polar bears (Ursus maritimus)

Greaves

Letcher

Sonne

et al. 2013

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…There is information from South American waters other than the one generated by the latter investigation; however, it comprises data from the north coast of Colombia (8), which in fact constitute the northern hemisphere. Although many investigations have shown higher PFC levels in biological samples from waters close to areas of concentrated industrialization and urbanization (5,(9)(10)(11), there are no previous studies on PFC levels in environmental samples from the most industrialized regions of the southern half of the planet.…”

Section: Introductionmentioning

confidence: 99%

High Accumulation of Perfluorooctane Sulfonate (PFOS) in Marine Tucuxi Dolphins (Sotalia guianensis) from the Brazilian Coast

Dorneles

Lailson‐Brito

Azevedo

et al. 2008

Environ. Sci. Technol.

View full text Add to dashboard Cite

Perfluorooctane sulfonate (PFOS) and other perfluoroalkyl compounds (PFCs) were measured in liver samples from 29 marine tucuxi dolphins from Rio de Janeiro state (RJ), Brazil. PFC measurement combined liquid chromatography and mass spectrometry, using a CapLC system connected to a Quadrupole-LIT mass spectrometer. PFOS was the only PFC detected and it was so in all samples. PFOS concentrations (ng · g -1 dw) of dolphins (n ) 23) from the highly contaminated Guanabara Bay (in RJ) varied between 43 and 2431 as well as between 76 and 427 from areas of RJ other than the quoted bay (n ) 6). Concentrations of three fetuses and one neonate varied between 664 and 1590. Fetus/mother ratios were calculated in two situations (2.75 and 2.62). It seems that mother-to-calf transference plays important role for relationships between PFOS and age. When a one-year-old male calf presenting 2431 ng · g -1 dw was excluded from the test, significant correlations were observed between PFOS concentrations and both age and total length. Despite the placental transference, PFOS concentrations were not significantly lower in females than in males. PFOS levels in marine tucuxi dolphins from Guanabara Bay are among the highest detected to date in cetaceans, and this may represent a threat to the small population concerned.

show abstract

“…In another study the authors reported higher PFOS levels in the spleen (6.2-131.5 ng g À1 ww) than in the liver (4.0-55.7 ng g À1 ww) of brown pelicans (Pelecanus occidentalis) followed by moderate concentrations in lung, kidney and brain (1.2-17.3 ng g À1 ww) and lowest concentrations in heart and muscle (o7 ng g À1 ww). [115] As high concentrations of PFOS were found in bile of pelicans (17-100 ng mL À1 ) it was assumed that biliary excretion might be a major pathway of elimination of PFOS from biota tissues. In the future more research into the tissue distribution of PFCs and the total body burden in birds is needed.…”

Section: Tissue Distribution Of Pfcs In Seabirdsmentioning

confidence: 99%

Trends of polyfluoroalkyl compounds in marine biota and in humans

Sturm

Ahrens

2010

Environ. Chem.

View full text Add to dashboard Cite

Environmental context. Polyfluoroalkyl compounds are used in a variety of industrial and consumer applications, including polymer production and for surface treatment of textiles and paper. Research over the last 10 years has shown that these compounds are ubiquitous environmental contaminants -they are extremely persistent, show toxic effects and accumulate in the food chain. We evaluate global, temporal and spatial trends of these important emerging contaminants.Abstract. This review gives an overview of existing knowledge of polyfluoroalkyl compounds (PFCs) in humans and in marine biota. Temporal trends and spatial distribution of PFCs were globally compared in humans, marine mammals, seabirds and fish. In general, PFC concentrations in the environment have increased significantly from the beginning of the production up to the 1990s. After the phase-out of perfluorooctane sulfonyl fluoride (POSF) production starting in 2000, PFC concentrations in humans generally decreased. In marine biota no clear temporal trends were observed. The temporal trends depended on the species, their trophic levels and the geographical locations. PFC patterns in humans and in marine wildlife species were compared regarding perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), their shorter and longer chain homologues (C 4 -C 15 ) and precursor compounds. Finally knowledge gaps were identified and recommendations for future work were presented.

show abstract

Perfluorooctanesulfonate and related fluorochemicals in biological samples from the north coast of Colombia

Cited by 85 publications

References 26 publications

Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in East Greenland polar bears (Ursus maritimus)

Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in East Greenland polar bears (Ursus maritimus)

High Accumulation of Perfluorooctane Sulfonate (PFOS) in Marine Tucuxi Dolphins (Sotalia guianensis) from the Brazilian Coast

Trends of polyfluoroalkyl compounds in marine biota and in humans

Contact Info

Product

Resources

About