2022
DOI: 10.1016/j.scitotenv.2022.156881
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Perfluorooctanesulfonic acid exposure altered hypothalamic metabolism and disturbed male fecundity

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Cited by 15 publications
(4 citation statements)
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“…In our previous studies, a higher dose of PFOS exposure (5 mg/g b.w. for 21 days) in mice, caused significant reduction in testosterone levels, sperm count, and sperm swimming activities (8,9,47). To decipher the underlying process of the reduced testosterone levels in the high-dose group, the analysis of the steroidogenic enzymes did not reveal noticeable changes, except a significant reduction of Srd5a2 (steroid 5a-reductase 2, a membrane enzyme catalyzes testosterone to dihydrotestosterone).…”
Section: Discussionmentioning
confidence: 97%
“…In our previous studies, a higher dose of PFOS exposure (5 mg/g b.w. for 21 days) in mice, caused significant reduction in testosterone levels, sperm count, and sperm swimming activities (8,9,47). To decipher the underlying process of the reduced testosterone levels in the high-dose group, the analysis of the steroidogenic enzymes did not reveal noticeable changes, except a significant reduction of Srd5a2 (steroid 5a-reductase 2, a membrane enzyme catalyzes testosterone to dihydrotestosterone).…”
Section: Discussionmentioning
confidence: 97%
“…Our previous study showed that in vitro PFOA exposure compromised the penetration ability of human spermatozoa by inducing oxidative stress, evoking CatSper-mediated Ca 2+ influx, and compromising progesterone-induced response ( 43 ). Testicular transcriptome profiling revealed that PFOS exposure led to alterations in microtubule-based movement, microtubule motor activity, cilium movement, cytoskeleton and spermatid development ( 51 ). In addition, PFOS altered sperm membrane lipid composition reflected by elevated ratio of cholesterol to phospholipids in male zebrafish ( 53 ), suggesting that PFOS may sperm function through disrupting membrane fluidity.…”
Section: Discussionmentioning
confidence: 99%
“…Correspondingly, rats exposed to PFOS also displayed a prominent decline in epididymal sperm count and sperm viability and motility, concomitant with a notable increase in the percentage of morphological abnormalities of head, mid-piece and tail of sperm ( 50 ). In another study, PFOS exposure at 5 mg/kg did not affect the number of sperm or the percentage of motile sperm, but significantly reduced the motility of sperm reflected by decreased curvilinear, straight-line and average path velocity in mice ( 51 ). In addition, exposure to PFOA and PFOS induced male reproductive toxicity in Caenorhabditis elegans , leading to a reduction in spermatid size and motility and an increase in sperm malformation rate ( 52 ).…”
Section: Effect Of Pfass On Human Sperm Quality and Quantitymentioning
confidence: 93%
“…However, to date, research studies on plant metabolisms of PBDEs mainly focus on the identification and quantification of phase I products, and sparse information is available on the detailed understanding of essential genes involved in transformation enzymes and therein molecular-biological mechanisms. Transcriptomics analysis is an effective strategy for quantitatively determining the differences of gene expression in the organisms under stress and is also an useful tool for investigating the molecular mechanisms of corresponding processes . To date, transcriptome analysis has been applied widely in the transformation of organohalides in plants, such as perfluorooctanesulfonic acid, decabromodiphenyl ethane, tetrachlorobisphenol A, and tetrachlorobiphenyl. However, the related genes and functional expression involved in the transformation of PBDEs in plant are still unclear.…”
Section: Introductionmentioning
confidence: 99%