Perfluorooctanoic acid (PFOA) affects steroidogenesis and antioxidant defence in granulosa cells from swine ovary

Basini, Giuseppina; Bussolati, Simona; Torcianti, Veronica; Grasselli, Francesca

doi:10.1016/j.etap.2023.104169

Cited by 11 publications

(1 citation statement)

References 53 publications

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“…In prepubertal rats, PFDoA decreased serum E2 level at an exposure level of 3 mg/kg/day [200]. In contrast, PFOA exposure increased E2 and P4 levels in swine granulosa cells [207]. Thus, there are variations in the endocrine effects; however, disruption to hormonal homeostasis by PFAS chemicals is supported.…”

Section: Endocrine Disruptionmentioning

confidence: 95%

Effects of Per- and Polyfluoroalkylated Substances on Female Reproduction

González-Alvarez,

Antwi-Boasiako,

Keating

2024

Toxics

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Per- and poly-fluoroalkylated substances (PFAS) are a large group of chemicals that persist both in the environment and in the body. Legacy PFAS, e.g., perfluorooctanoic acid and perfluorooctane sulfonic acid, are implicated as endocrine disruptors and reproductive and developmental toxicants in epidemiological and animal model studies. This review describes female reproductive outcomes of reported studies and includes where associative relationships between PFAS exposures and female reproductive outcomes have been observed as well as where those are absent. In animal models, studies in which PFAS are documented to cause toxicity and where effects are lacking are described. Discrepancies exist in both human and animal studies and are likely attributable to human geographical contamination, developmental status, duration of exposure, and PFAS chemical identity. Similarly, in animal investigations, the model used, exposure paradigm, and developmental status of the female are important and vary widely in documented studies. Taken together, support for PFAS as reproductive and developmental toxicants exists, although the disparity in study conditions and human exposures contribute to the variation in effects noted.

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Section: Endocrine Disruptionmentioning

confidence: 95%