Perforated cecal diverticulitis with CT diagnosis and medical management

Tsetse, Caleb; Chaudhry, Shazia R.; Jabi, Feraas; Taylor, Jennifer Nicole

doi:10.1016/j.radcr.2018.08.030

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…Diverticula are outpouchings of bowel wall which may be congenital or may form in areas of weakness, usually due to increased intraluminal pressure or trauma where the vasa recta penetrate the bowel wall [7]. True diverticula involve all three layers of bowel wall, whereas pseudodiverticula typically do not involve the muscular layer and are more prone to inflammation and perforation, as seen with sigmoid diverticulitis [7]. While left-sided colonic diverticular disease is common in Western countries and is largely thought to be related to diet, right-sided disease is considered rare [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

“…There may be the presence of a palpable abdominal mass where fecalomas are present [10]. Computed tomography is the imaging modality of choice in diagnosis of right-sided colonic diverticular disease with 98% sensitivity and specificity, particularly in differentiating the presentation from acute appendicitis [2,7,9]. Additionally, findings on CT scans which may indicate a stercoral perforation include the presence of free gas (including extraluminal gas locules), the presence of fecal impaction or fecaloma, thickening of the involved colonic wall, and surrounding fat-stranding [5,10].…”

Section: Discussionmentioning

confidence: 99%

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Stercoral perforation of a cecal diverticulum: A rare presentation

Quarmby

Balasooriya

2022

J Case Rep Images Surg

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Introduction: Right-sided diverticular disease, including cecal diverticulum, is a relatively uncommon occurrence when compared to left-sided diverticular disease, particularly in Western countries. Even more rare than this is the perforation of these diverticulum due to stercoral colitis. Case Report: We report the case of an 83-year-old man who presented to the Emergency Department with a relatively brief history of periumbilical and right lower quadrant pain, associated with nausea and low-grade fevers, and a computed tomography (CT) scan demonstrating perforation of a large cecal diverticulum requiring acute surgical management. Conclusion: Perforation of a cecal diverticulum is rare, particularly when due to stercoral colitis, and can be often misdiagnosed. It should be considered in the context of the systemically unwell older patient with a history of constipation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Stercoral perforation of a cecal diverticulum: A rare presentation

Quarmby

Balasooriya

2022

J Case Rep Images Surg

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“…It is estimated that ultrasound has a sensitivity of 91.3% and a sensitivity of 99.8% with an overall accuracy of 99.5% in the diagnosis of cecal diverticulitis. Recent literature clearly states that CT scan is superior to ultrasound (4), with a specificity and sensitivity values around 98% (11). There are some CT features that can help in the differentiation of benign from malignant causes, where there is a focal asymmetric and eccentric bowel wall thickening (with less than 5cm).…”

Section: Discussion Discussionmentioning

confidence: 99%

Lesson from a Cecal Phlegmon: From an Acute Appendicitis to a Solitary Cecal Diverticulitis

Gonçalves¹,

Pinto²,

Pereira³

et al. 2021

SGO

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A cecal phlegmon can be a difficult situation for a surgeon, since the treatment strategy must be decided with uncertainty of the phlegmon's origin: benign or malignant. The most common causes are cecal diverticulitis, acute appendicitis and cecal carcinoma. More rarely, it can be caused by a appendicular diverticulitis (1). In this case, we present a case of a cecal diverticulum, which is a rare but benign medical condition, in a 52-year-old man who presented to the emergency department with a 3-day constant abdominal pain in the right lower quadrant with rebound and with an increase of the inflammatory analytical levels. An abdominal ultrasound showed findings compatible with an acute appendicitis and the patient was proposed to a laparoscopic appendectomy. Intraoperatively, a cecal phlegmon was found and an ileocecal resection with primary anastomosis was conducted. Histopathological findings confirmed a rare solitary cecum diverticulitis.

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“…The downstream target genes of miR‐221‐3p were predicted with the help of Targetscan (http://www.targetscan.org/vert_72/; Agarwal, Bell, Nam, & Bartel, 2015), miRDB (http://mirdb.org/; Chen & Wang, 2020), and miRWalk (http://mirwalk.umm.uni-heidelberg.de/; Tsetse, Chaudhry, Jabi, & Taylor, 2019) databases. The potential binding sites of miR‐221‐3p and Gab1 were predicted with the help of the Targetscan database.…”

Section: Methodsmentioning

confidence: 99%

Mechanism of METTL3‐mediated m6A modification in depression‐induced cognitive deficits

Niu

Wang

Zhou

2022

American J of Med Genetics Pt B

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Depressive disorder (DD) is associated with N6-methyladenosine (m6A) hypermethylation. This study sought to explore the molecular mechanism of Methyltransferase-like 3 (METTL3) in cognitive deficits of chronic unpredictable mild stress (CUMS)-treated rats and provide novel targets for DD treatment. A DD rat model was established via CUMS treatment. Cognitive deficits were assessed via body weighing and behavioral tests. METTL3, microRNA (miR)-221-3p, pri-miR-221, GRB2-associated binding protein 1 (Gab1) expressions in hippocampal tissues were detected via RT-qPCR and Western blotting. m6A, DiGeorge syndrome critical region gene 8 (DGCR8)-bound pri-miR-221 and pri-miR-221 m6A levels were measured. The binding relationship between miR-221-3p and Gab1 was testified by dual-luciferase and RNA pull-down assays. Rescue experiments were designed to confirm the role of miR-221-3p and Gab1. METTL3 was highly expressed in CUMS rats, and silencing METTL3 attenuated cognitive deficits of CUMS rats. METTL3-mediated m6A modification facilitated processing and maturation of pri-miR-221 via DGCR8 to upregulate miR-221-3p. miR-221-3p targeted Gab1. miR-221-3p overexpression or Gab1 downregulation reversed the role of silencing METTL3 in CUMS rats. Overall, METTL3-mediated m6A modification facilitated processing and maturation of pri-miR-221 to upregulate miR-221-3p and then inhibit Gab1, thereby aggravating cognitive deficits of CUMS rats.

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Perforated cecal diverticulitis with CT diagnosis and medical management

Cited by 5 publications

References 19 publications

Stercoral perforation of a cecal diverticulum: A rare presentation

Stercoral perforation of a cecal diverticulum: A rare presentation

Lesson from a Cecal Phlegmon: From an Acute Appendicitis to a Solitary Cecal Diverticulitis

Mechanism of METTL3‐mediated m6A modification in depression‐induced cognitive deficits

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