Perforated Gastrointestinal Stromal Tumor of the Meckel’s Diverticulum: a Case Report and Review of Literature

Hosamani, Ishwar; Kodaganur, Srinivas; Chaukimath, S M

doi:10.1007/s12262-016-1525-7

Cited by 10 publications

(8 citation statements)

References 35 publications

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“…All patient data were combined to create this report. There have been 18 cases of GIST in perforated Meckel's diverticulum, as shown in Table 1 [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. No recurrences were reported.…”

Section: Discussionmentioning

confidence: 99%

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Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review

et al. 2020

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Introduction Gastrointestinal stromal tumor (GIST) is rare neoplasms of the gastrointestinal tract associated with high rates of malignant transformation. GIST has been found largely in the stomach, small bowel, colon and rectum, and esophagus, but about 5% are found in other locations. We herein report a 56-year-old woman with a GIST in perforated Meckel's diverticulum. After encountering this patient, a review of the literature found reports of 18 similar patients. Case presentation A 56-year-old woman diagnosed with galactosialidosis (β-galactosidase-neuraminidase deficiency) presented with vomiting. On contrast-enhanced computed tomography, peritonitis due to perforation of the intestine was diagnosed based on the free air and dilated loop of the small bowel. Laparotomy revealed perforation of Meckel’s diverticulitis located 50 cm from the ileocecal valve. Partial resection of the ileum, including the diverticulum, and end-to-end anastomosis of the small intestine were performed. Regarding the pathological findings, the edge of the diverticulum wall consisted of a solid mass measuring 1.0 cm in size, and the tumor cells were spindle-shaped with 1 mitosis present per 50 high-power fields. The diagnosis was established as GIST of the Meckel's diverticulum. The postoperative period was uneventful. Follow-up at two years revealed no evidence of recurrence. Conclusion GIST in perforated Meckel's diverticulum is very rare. The potential for the coexistence of GIST or other tumor should be considered in the treatment of perforated Meckel's diverticulum.

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Section: Discussionmentioning

confidence: 99%

“…In the review, almost all of the patients required small bowel resection. Since 2013, seven patients underwent imatinib chemotherapy after their operation [19][20][21][22][23][24][25]. The tumors ranged in longitudinal length from 1 to 14 cm.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review

et al. 2020

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“…There are other interesting case reports of perforated GIST in Meckel's diverticulum and a case of Torricelli-Bernoulli sign. 6 GIST are submucosal in origin. Most submucosal GI tumours require surgical resection regardless of histology.…”

Section: Discussionmentioning

confidence: 99%

A rare scenario of perforated gastrointestinal stromal tumours of ileum

et al. 2020

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Gastro-intestinal stromal tumours (GIST) are among the common mesenchymal tumours of the gastro-intestinal (GI) tract. It varies in location and presentation. GIST are reported in the stomach frequently (60-70%), followed by small intestine (20-25%). Mainly GIST manifest typically with bleeding or vague abdominal pain and discomfort. The spontaneous perforation of GIST is very rare. We report case of a middle-age male patient who presented in emergency with pain in right lower abdomen associated with features of peritonism. After clinical evaluation and preliminary radiological investigations, a working diagnosis of perforated appendix was made. Patient was undertaken for emergency surgery. A diagnostic laparoscopy followed by midline laparotomy was done. Intra-operatively, a perforated and necrotic outpouching at antimesenteric border of terminal ileum was found. Histopathological examination of the resected part of ileum revealed compatibility with GIST. It was strongly positive for cluster of differentiation 117 (CD117) and smooth muscle actin. Patient received adjuvant therapy with Imatinib. A complete surgical resection without extensive lymph node sampling is the primary treatment option. As GIST are rare, a high index of suspicion is warranted for diagnosis and appropriate treatment.

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“…Other less common presentations of GIST are mass, weight loss, and sign and symptoms of obstruction as nausea, vomiting, obstipation, etc. Some rare presentations as perforation are reported in literatures (11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Co-Incidence of Paraesophageal Hernia and Perforated Gastrointestinal Stromal Tumor: A Case Report on Rare Presentation of GIST

et al. 2021

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Introduction: The most common connective tissue neoplasm of the gastrointestinal tract is gastrointestinal stromal tumors (GISTs). Its presentations are usually abdominal pain and gastrointestinal bleeding. Case Presentation: We report a 31-year-old man with abdominal pain presented to our hospital with 10 days history of abdominal pain. After radiologic investigations, total distended stomach paraesophageal hernia and antral deformity were seen in the CT scan. Subsequently, the patient underwent surgery and after releasing the stomach, a large sealed perforated mass was seen in the antrum near the diaphragmatic hiatus and small localized abscess that subtotal gastrectomy and hernia repair was done. Pathologic examination revealed that the perforated mass is a GIST. Conclusions: We report a rare complication of gist that is perforation and the first report of simultaneous paraesophageal hernia and perforated gist.

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Perforated Gastrointestinal Stromal Tumor of the Meckel’s Diverticulum: a Case Report and Review of Literature

Cited by 10 publications

References 35 publications

Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review

Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review

A rare scenario of perforated gastrointestinal stromal tumours of ileum

Co-Incidence of Paraesophageal Hernia and Perforated Gastrointestinal Stromal Tumor: A Case Report on Rare Presentation of GIST

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