Perforating Milia‐like Idiopathic Calcinosis Cutis and Periorbital Syringomas in a Girl With Down Syndrome

Schepis, Carmelo; Siragusa, Maddalena; Palazzo, Rosaria; Batolo, D; Romano, Corrado

doi:10.1111/j.1525-1470.1994.tb00598.x

Cited by 40 publications

(26 citation statements)

References 8 publications

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“…Ages range from 6 months through adolescence (4), with most lesions resolving by adulthood (6). Prior reports suggest that lesions of MICC tend to occur on the hands and feet, although other sites may be involved, including the face and acrosyringia (7). Palpebral and perilesional syringomas have also been described in children with MICC, although an association is unclear because of the frequency of syringomas in Down syndrome (6), although Berk reported syringomas and MICC in a patient without Down syndrome (8).…”

Section: Discussionmentioning

confidence: 99%

Acral Milia‐Like Idiopathic Calcinosis Cutis in a Child with Down Syndrome: Report of a Case, Review of the Literature, and Description of Dermoscopic Findings

Fox¹,

Mehregan²,

Jablonowski³

2012

Pediatric Dermatology

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Milia-like idiopathic calcinosis cutis (MICC) is a rare dermopathy, usually occurring in children with Down syndrome. We report a case of an 8-year-old girl with Down syndrome who presented with histologically verified MICC, briefly review the literature on MICC, discuss the differential diagnosis, and describe the use of dermoscopy in the evaluation of lesions, which we believe has never been published previously with this entity.

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Section: Discussionmentioning

confidence: 99%

Acral Milia‐Like Idiopathic Calcinosis Cutis in a Child with Down Syndrome: Report of a Case, Review of the Literature, and Description of Dermoscopic Findings

Fox¹,

Mehregan²,

Jablonowski³

2012

Pediatric Dermatology

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“…Then, the content dilates the acrosyringium and is cleaved in the upper dermis and eventually expelled by a perforation [25]. Milia-like idiopathic calcinosis cutis is associated coincidentally with palpebral syringomas [26]. …”

Section: Discussionmentioning

confidence: 99%

An Updated Survey on Skin Conditions in Down Syndrome

et al. 2002

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Background: Only three not concordant surveys have been published on skin conditions associated with Down syndrome. Objective: A sample ranging from infancy to adulthood, using acknowledged criteria for diagnosis, may highlight the skin involvement in Down syndrome. Methods: We report the skin conditions observed in 203 people with Down syndrome, separated according to five different age ranges. We have set up two main groups of skin features: the phenotype and the dermatological diseases. Results: The single palmar crease and xerosis are strongly represented within the phenotype. Among the dermatological diseases, folliculitis and syringomas have been observed mainly in adolescence and adulthood. Atopic dermatitis has been recognized in 10 subjects. Alopecia areata and milia-like idiopathic calcinosis cutis appeared in 6 subjects. Conclusion: People with Down syndrome suffer from peculiar dermatoses (syringomas, milia-like calcinosis, elastosis perforans serpiginosa). Other conditions (folliculitis, alopecia areata) are frequently observed.

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“…Idiopathic calcification occurs in the absence of evident tissue or metabolic abnormalities. Three distinctive disorders of childhood included in this group are milia‐like calcinosis cutis associated with Down syndrome (9), idiopathic calcinosis of the scrotum (10), and subepidermal calcified nodule of Winer (11).…”

Section: Discussionmentioning

confidence: 99%

Calcinosis Cutis Following Liver Transplantation in a Pediatric Patient

Larralde

Giachetti

Kowalczuk

et al. 2003

Pediatric Dermatology

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We report the occurrence of calcinosis cutis in a 3-year-old girl after liver transplantation. The cutaneous lesions consisted of 5 mm white papules on an erythematous base in linear and rosette configurations that developed in the abdominal and lumbar areas 10 days after transplantation. The patient had received calcium chloride solution intravenously during surgery. We excluded other causes of ectopic calcification such as hyperparathyroidism, renal failure, and extravasation of calcium solution. We discuss the etiology of calcinosis cutis after liver transplantation. This sequence of events has not been previously described in pediatric patients.

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Perforating Milia‐like Idiopathic Calcinosis Cutis and Periorbital Syringomas in a Girl With Down Syndrome

Abstract: An 11-year-old girl with Down syndrome had whitish, milia-like lesions on the acral areas of the limbs, and periorbital syringomas. Calcium deposits were the histologic counterparts of the milia-like lesions. This is the first European report of this feature in Down syndrome.

Cited by 40 publications

References 8 publications

Acral Milia‐Like Idiopathic Calcinosis Cutis in a Child with Down Syndrome: Report of a Case, Review of the Literature, and Description of Dermoscopic Findings

Acral Milia‐Like Idiopathic Calcinosis Cutis in a Child with Down Syndrome: Report of a Case, Review of the Literature, and Description of Dermoscopic Findings

An Updated Survey on Skin Conditions in Down Syndrome

Calcinosis Cutis Following Liver Transplantation in a Pediatric Patient

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