Perforin and Fas pathways of cytotoxic T‐cells in histiocytic necrotizing lymphadenitis

Ohshima, Koichi; Shimazaki, Kae; Kume, Tohru; Suzumiya, Junji; Kanda, Motonobu; Kikuchi, Masahiro

doi:10.1046/j.1365-2559.1998.00532.x

Cited by 80 publications

(59 citation statements)

References 24 publications

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“…The histologic and immunologic findings together with the typical clinical presentation suggest a hyperimmune reaction of immune cells to unidentified agents. 3,4,25 An autoimmune contribution to the pathogenesis is suggested by observations showing that the disease can precede or occur in association with systemic lupus erythematosus. 4,7,10,26 A definitive diagnosis of KFD is determined by a lymph node biopsy.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease With Prolonged Fever in Children

2004

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ABSTRACT. We reviewed 12 patients who had Kikuchi-Fujimoto disease (KFD) and presented with prolonged fever and lymphadenopathy. The clinical and laboratory aspects of the patients confirmed by excisional lymph node biopsy were analyzed. The mean age of the children was 11.0 ؎ 3.0 years (range: 6 -15 years). The male-to-female ratio was 1.4:1. The median duration of fever before admission and the total duration of fever was 13 days (range: 7-65 days) and 19.5 days (range: 9 -75 days), respectively. One patient had supraclavicular lymphadenopathy, 10 had cervical involvement, and 1 had axillary lymphadenopathy. All of the histologic findings of the lymph node biopsies showed the characteristic findings consistent with KFD, such as paracortical necrosis with karyorrhexis and an increase in the number of phagocytic histiocytes and atypical lymphocytes. As for the laboratory findings, leukopenia (3600 ؎ 900 per mm 3 ), anemia (hemoglobin 11.4 ؎ 1.2 g/dL), an elevated erythrocyte sedimentation rate (44 ؎ 18 mm/hour), and a relatively low C-reactive protein level (1.3 ؎ 1.1 mg/dL) were noted. Eight patients received conservative therapy with antipyretics, and 3 patients were treated with prednisolone. KFD is a rare disease yet should be considered in the differential diagnosis for older children with prolonged fever and lymphadenopathy.

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Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease With Prolonged Fever in Children

2004

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“…Double staining for MIG & CXCR3 and TARC & CCR4 were performed on paraffin samples using previously reported methods. 16 Briefly, after deparaffinization, sections were washed in PBS (pH 7.2), incubated with horse serum and reacted with a polyclonal rabbit anti-human antibody, biotinylated goat anti-rabbit fragments and avidin horseradish peroxidase and mouse peroxidase anti-peroxidase complex. After each incubation sections were washed in PBS.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Infiltration of Th1 and Th2 lymphocytes around Hodgkin and Reed‐Sternberg (H&RS) cells in Hodgkin disease: Relation with expression of CXC and CC chemokines on H&RS cells

Ohshima

Tutiya

Yamaguchi

et al. 2002

Intl Journal of Cancer

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Key words: TARC; IP10; MIG; CXCR3; Hodgkin diseaseHodgkin disease (HD) differs morphologically, immunologically and clinically from non-Hodgkin lymphoma (NHL). Morphologically, most cases of NHL consist of a relatively homogeneous population of neoplastic cells, whereas HD consists predominantly of reactive cells with only a few neoplastic cells. Recent studies of single Hodgkin and Reed-Sternberg (H&RS) cells have indicated that these cells may be derived from germinal center B-cells, 1,2 however, the pathogenesis of HD remains uncertain. The lymphocytes surrounding H&RS cells are thought to represent a reaction by the host immune system against the neoplastic H&RS cells. The small lymphocytes immediately surrounding the H&RS cells are mostly CD4 ϩ T cells that express early activation markers. 3 The absence of prominent specific cytotoxic T cell (CTL) or natural killer (NK) cell populations surrounding the H&RS cells appears to argue against a Th1-type response, whereas the occasional prominent admixture of plasma cells and eosinophils is suggestive of a Th2-type response. 4 The clinical features of HD, such as fever, weight loss and night sweating, suggest the involvement of cytokines in this disease. 5 Previous studies have shown that H&RS cells express various cytokines including interleukin (IL)-1, IL-5, IL-6, IL-9, IL-13, tumor necrosis factor (TNF)-␣, monocyte-colony stimulating factor (M-CSF), tumor growth factor (TGF)-␤ and CD80. 6,7 In addition, few studies have addressed the role of chemokines in HD. 8 Chemokines are members of a family of small secreted proteins, ranging in size from 8 -12 kD. They are divided into 4 major families including the CXC-, CC-, C-and CX3C-families. 9,10 Some chemokines have received considerable attention because they display selectivity of cell targets and receptors. This selectivity has suggested the possibility that the cellular composition of inflammatory responses may, in part, be a function of locallyproduced chemokines at specific sites. 9,10 Studies based mainly on reverse-transcription polymerase chain reaction (RT-PCR) technology have shown that HD tissues also express higher levels of inducible protein 10 (IP10), monokine induced by interferon ␥ (MIG), regulated on activation, normal T cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1␣ and in particular, eotaxin, compared to control lymph nodes. 11,12 It has been demonstrated recently that the T cell-directed chemokine thymus-and activation-regulated chemokine (TARC), IP10 and MIG are also expressed in H&RS cells. 11,13 IP10 and MIG function through the CXCR3 receptor on activated Th1 T cells and NK cells. TARC function through the CCR4 receptor on activated Th2 T cells. MIP-1␣ and RANTES share the CCR1 receptor on eosinophils, the CCR5 receptor on NK cells and both the CCR1 and CCR5 receptors on monocytes and activated Th1 T cells. Eotaxin functions through the CCR3 receptor on eosinophils and activated Th2 T cells. 8,11,12,14 The present study was designed to investigate the expre...

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“…These three observations are closely related, and they suggest that T-lymphocyte apoptosis may play an important role in the pathogenesis of HNL. 9 The incidence of pleural effusion in HNL is low and rarely reported clinically, so we cannot reach any conclusion regarding the likelihood that HNL patients might have pleural effusion. In the present case, the patient had an exudate.…”

Section: Discussionmentioning

confidence: 90%

Report of a rare case of histiocytic necrotizing lymphadenitis with bilateral pleural effusion diagnosed via cervical lymph node biopsy

2017

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CONTEXT: Histiocytic necrotizing lymphadenitis (HNL) is a rare disorder that is often benign and selflimiting. There have been reports of co-occurrence of HNL with other diseases, including systemic lupus erythematosus, hemophagocytic syndrome and antiphospholipid syndrome. CASE REPORT: Here, we report a case in which a patient experienced unexplained fever, swelling of the cervical lymph node and bilateral pleural effusion and was ultimately diagnosed with HNL based on results from a lymph node biopsy. After treatment with glucocorticoid, the patient regained normal body temperature, the swelling of the lymph nodes disappeared and the pleural effusion was reabsorbed. CONCLUSIONS:The pathogenesis of HNL remains unclear, and pleural effusion is rarely reported in HNL patients. We presented this case to improve diagnostic awareness of this condition among clinicians and help reduce the likelihood of misdiagnosis.

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Perforin and Fas pathways of cytotoxic T‐cells in histiocytic necrotizing lymphadenitis

Cited by 80 publications

References 24 publications

Kikuchi-Fujimoto Disease With Prolonged Fever in Children

Kikuchi-Fujimoto Disease With Prolonged Fever in Children

Infiltration of Th1 and Th2 lymphocytes around Hodgkin and Reed‐Sternberg (H&RS) cells in Hodgkin disease: Relation with expression of CXC and CC chemokines on H&RS cells

Report of a rare case of histiocytic necrotizing lymphadenitis with bilateral pleural effusion diagnosed via cervical lymph node biopsy

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