Various methods to control thermal conditions of building spaces have been developed to investigate their performances of energy use and thermal comfort in the system levels. However, the high control precision used in several studies dealing with data-driven methods may cause energy increases and the high energy efficiency may be disadvantageous for maintaining indoor environmental quality. This study proposes a model that optimizes the supply air condition to effectively reach the setting values by two-way controls of the supply air conditions. In such a process, if the results of the thermal comfort level are outside the range of the initial setting values, an adaptive model starts to work to send additional signals to adjust the set-point temperature. In order to assess its efficiency, the conventional thermostat model and fuzzy deterministic model are adopted as comparators. Comparing the results of the proposed network-based model with conventional control models, an improved control performance from 15.5% to 29.3% in thermal comfort indices was identified, as well as an over 30% improvement in energy efficiency. As a consequence, the network-based adaptive control rule supervising thermal comfort indices properly operates to abate increases in its energy use without compromising its thermal comfort. This performance can be significant in places where many spaces are woven at high density, and in situations where better thermal comfort can increase users’ workability and productivity.