This paper reports on a novel biosensor structure and the effects of including thermionic emission in an electrically-doped tunnel field-effect transistor (TFET). We present a comparative analysis between two biosensors based on a pure tunneling transistor and a transistor which combines the tunnelling and thermionic emission carrier transport in the same device. We first discuss the physics of TFET when vertical thermionic emission is included with horizontal tunneling through an additional electron source. Subsequently, the biosensor was designed using the combined mechanism structure and a comparative analysis of biosensors was done in terms of various DC and RF parameters for different biomolecules of proteins. Moreover, workfunction engineering was implemented to the combined mechanism biosensor and sensitivity was analyzed by drain current and transconductance.