The implementation of an in-band full-duplex wireless communication system is demonstrated in this study. In the analog/RF domain, the self-interference(SI) signal is reduced using a separate antenna for the transmitter and receiver paths, and most of the SI signal is canceled in the digital domain. A software defined radio(SDR) is used to implement the in-band full-duplex wireless communication system. The USRP X310 device uses transmitting and receiving antennas. By adjusting the gain of the transmitting and receiving ends of the SDR device, the magnitude of the SI signal entering the receiving antenna, and the size of the received signal from the outside, are both set to −64 dB. To verify the in-band full-duplex wireless communication performance, the source data is image and orthogonal frequency-division multiplexing is used for modulation. A WiFi standard frame with a carrier frequency of 2.67 GHz and bandwidth of 20 MHz is used. In the received signal, the SI signal is canceled by digital signal processing and the SI signal is attenuated by up to 34 dB. OFDM demodulation was impossible when the SI signal was not removed. However, the bit error rate is reduced to 2.63×10 −5 when the SI signal is attenuated by 34 dB, and no error is detected in the 100 Mbit data output as a result of passing through the Viterbi decoder.