In this investigation, the common rail direct injection (CRDI) single cylinder four stroke diesel engine has made to modify in terms of toroidal reentrant combustion chamber (TRCC) shape and 7 holes CRDI nozzle injector. The current experimental study objective is to optimization of multiple injection strategy (MIS) in modified CRDI diesel engine powered with palm oil methyl ester (POME) B100 and diesel fuels. In the first phase of work, experiment results showed that slightly improved in brake thermal efficiency (BTE) and reduced emissions except oxides of nitrogen (NO x ) for POME fuelled engine operates under optimized MIS, fuel injection timing (IT) of -10° before top dead center (BTDC) and 600 bar injection pressure (IOP) in modified CRDI diesel engine. In the second phase of work, the performance of modified CRDI diesel engine is improved by increasing IOP from 600 bar to 900 bar at same MIS and fuel IT. The second phase of experiment results showed that percentage of increase in BTE by 2.47%, peak pressure (PP) by 13.69%, heat release rate (HRR) by 17.64%, NO X by 11.70% and percentage of decreased in ignition delay (ID) by 29.62%, combustion duration (CD) by 13.79%, unburnt hydrocarbon (UBHC) by 19.04%, carbon monoxide (CO) by 14.28%, smoke level by 20.93% as compared to first phase of work in modified CRDI diesel engine fuelled with POME.