Performance and Head-to-Head Comparison of Three Clinical Models to Predict Occurrence of Postthrombotic Syndrome: A Validation Study

Abstract

Objective: The SOX-PTS, Amin, and Méan models are three different clinical prediction scores stratifying the risk for post-thrombotic syndrome (PTS) development in patients with acute deep vein thrombosis (DVT) of the lower limbs. Herein, we aimed to assess and compare these scores in the same cohort of patients. Methods: We retrospectively applied the three scores in a cohort of 181 patients (196 limbs) who participated in the SAVER pilot trial for an acute DVT. Patients were stratified into PTS-risk groups using positivity thresholds for high-risk patients as proposed in the derivation studies. All patients were assessed for PTS 6 months after index DVT using the Villalta scale. We calculated the predictive accuracy for PTS and area under receiver operating characteristic (AUROC) curve for each model. Results: The Méan model was the most sensitive (Sensitivity 87.7%; 95% CI: 77.2-94.5) with the highest negative predictive value (87.5%; 95% CI: 76.8-94.4) for PTS. The SOX-PTS was the most specific score (Specificity 97.5 %; 95% CI: 92.7-99.5) with the highest positive predictive value (72.7%; 95% CI: 39.0-94.0). The SOX-PTS and Méan models performed well for PTS prediction (AUROC 0.72; 95% CI: 0.65-0.80 and 0.74; 95% CI: 0.67-0.82), whereas the Amin model did not (AUROC 0.58; 95% CI: 0.49-0.67). Conclusions: Our data support the SOX-PTS and Méan models have good accuracy to stratify the risk for PTS.

A systematic review and meta-analysis of risk prediction models for post-thrombotic syndrome in patients with deep vein thrombosis

“…In terms of model performance, the discrimination of most prediction models was between 0.7 and 0.8, and the pooled discrimination of meta-analysis was 0.75, which was moderate accuracy. Michelle Pradier conducted a study to assess the performance of SOX-PTS score ( Anat Rabinovich，2018 [ 18 ]), Méan model ( Marie Méan, 2018 [ 19 ]) and Amin model ( Elham E. Amin, 2018 [ 20 ]) in SAVER database [ 27 ]. The result showed that, the performance of the SOX-PTS score and the Méan model were acceptable with an AUC of 0.72 and 0.74 respectively.…”