Performance and Interpretation of Clot Waveform Analysis

Ruberto, Maria; Marongiu, Francesco; Barcellona, Doris

doi:10.1007/978-1-0716-3175-1_9

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…The composites were characterized by a complex of physio-mechanical and biological-biochemical tests. The main purpose of the presented paper is to assess the major blood coagulation parameters of the PLA-Zn composites, namely the Activated Partial Thromboplastin Time (aPTT) and Prothrombin Time (PT) [118].…”

Section: Introductionmentioning

confidence: 99%

Activity in the Field of Blood Coagulation Processes of Poly(Lactide)-Zinc Fiber Composite Material Obtained by Magnetron Sputtering

Mrozińska,

Ponczek,

Kaczmarek

et al. 2024

Coatings

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This article presents the biochemical properties of poly(lactide)-zinc (PLA-Zn) composites obtained by DC magnetron sputtering of zinc onto melt-blown nonwoven fabrics. The biochemical properties were determined by the evaluation of the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The antimicrobial activity of the PLA-Zn samples was additionally tested against representative Gram-positive and Gram-negative bacteria strains. A structural study of the PLA-Zn has been carried out using specific surface area and total pore volume (BET) analysis, as well as atomic absorption spectrometry with flame excitation (FAAS). PLA-Zn composites exhibited an antibacterial effect against the analyzed strains and produced inhibition zones against E. coli and S. aureus. Biochemical investigations revealed that the untreated PLA fibers caused the acceleration of the clotting of human blood plasma in the intrinsic pathway. However, the PLA-Zn composites demonstrated significantly different properties in this regard, the aPTT was prolonged while the PT was not altered.

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Section: Introductionmentioning

confidence: 99%

Activity in the Field of Blood Coagulation Processes of Poly(Lactide)-Zinc Fiber Composite Material Obtained by Magnetron Sputtering

Mrozińska,

Ponczek,

Kaczmarek

et al. 2024

Coatings

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Biochemical Behavior, Influence on Cell DNA Condition, and Microbiological Properties of Wool and Wool–Copper Materials

Mrozińska,

Kaczmarek,

Świerczyńska

et al. 2024

Materials

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The paper presents the study concerning the preparation and physio-chemical and biological properties of wool–copper (WO-Cu) materials obtained by the sputter deposition of copper onto the wool fibers. The WO-Cu material was subjected to physio-chemical and biological investigations. The physio-chemical investigations included the elemental analysis of materials (C, N, O, S, and Cu), their microscopic analysis, and surface properties analysis (specific surface area and total pore volume). The biological investigations consisted of the antimicrobial activity tests of the WO-Cu materials against colonies of Gram-positive (Staphylococcus aureus) bacteria, Gram-negative (Escherichia coli) bacteria, and fungal mold species (Chaetomium globosum). Biochemical–hematological tests included the evaluation of the activated partial thromboplastin time and pro-thrombin time. The tested wool–copper demonstrated the ability to interact with the DNA in a time-dependent manner. These interactions led to the DNA’s breaking and degradation. The antimicrobial and antifungal activities of the WO-Cu materials suggest a potential application as an antibacterial/antifungal material. Wool–copper materials may be also used as customized materials where the blood coagulation process could be well controlled through the appropriate copper content.

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Clot Waveform Analysis: From Hypercoagulability to Hypocoagulability: A Review

Marongiu,

Ruberto,

Marongiu

et al. 2024

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Prothrombin time (PT) and activated partial thromboplastin time (aPTT) are coagulative screening tests used for the diagnosis of several pathologic conditions, such as liver failure, coagulation factor deficiencies, anti-phospholipid antibodies (lupus anticoagulant), and factor VIII inhibitors. A new test was developed several years ago to detect the amount of thrombin generated during plasma clotting, using low tissue factor concentrations and fluorogenic substrates, and it has since been used successfully in conditions ranging from hypocoagulable to hypercoagulable states. However, the test is expensive and difficult to perform in nonspecialized laboratories, and efforts have thus been made to find an economic and easily implementable test suitable for routine use, even in nonspecialist laboratories. Objective.— To evaluate clot waveform analysis (CWA) of PT and aPTT, aiming to show the dynamics of clot formation; that is, the “hidden” features of both tests. CWA can be implemented by using an automated coagulometer with dedicated software. The aim of this review was to evaluate whether CWA is able to detect both hypercoagulative and hypocoagulative states. Data Sources.— Using MedLine, we searched and retrieved articles relating to CWA. We only considered articles published in English, but with no limits in terms of article type, publication year, or geography. Conclusions.— CWA was shown to be a reliable test in patients with both hypercoagulable and hypocoagulable states. It represents a simple and inexpensive global test that can easily provide information on the behavior of the coagulation system. Both the first and second derivatives are computed by using dedicated software implemented with an on-board algorithm in a routine automated coagulometer.

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Performance and Interpretation of Clot Waveform Analysis

Cited by 3 publications

References 32 publications

Activity in the Field of Blood Coagulation Processes of Poly(Lactide)-Zinc Fiber Composite Material Obtained by Magnetron Sputtering

Activity in the Field of Blood Coagulation Processes of Poly(Lactide)-Zinc Fiber Composite Material Obtained by Magnetron Sputtering

Biochemical Behavior, Influence on Cell DNA Condition, and Microbiological Properties of Wool and Wool–Copper Materials

Clot Waveform Analysis: From Hypercoagulability to Hypocoagulability: A Review

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