Due to their soft structure and covering material, plastic greenhouses are vulnerable to wind disasters, causing large-scale damage and huge economic losses. The wind load of greenhouses depends on the surface wind pressure distribution, which is different for greenhouses located in valleys from those in plain areas. To study the wind pressure distribution law for various regions of greenhouses built in valleys, mountain and greenhouse models have been built by Computational Fluid Dynamics, in which the length direction of the greenhouse is perpendicular to the valley and the wind direction is parallel to the valley. In the analysis, the verified turbulence model and grid division method are both introduced, and the effect of the height and distance of mountains is considered. According to the distribution law of wind pressure, the greenhouse’s surface is partitioned, and the variation law of the shape factor of wind load on a plastic tunnel is analyzed. Then, the calculation model for the shape factor of the wind load on the greenhouse located in a valley is proposed. The conclusions show that: (a) When the wind inflow direction angle is parallel to the valley, the distribution pattern of wind pressure on the surface of the greenhouse is similar to that on the plain regardless of the distance and height of the mountains, while the values of the wind pressure are greatly affected by the mountain height and distance. The distance between mountains has greater influence than the effect of mountain height. (b) The shape factor of wind load on the suction area of the greenhouse decreases as the distance of mountains increases, while the shape factor on the pressure area of the greenhouse increases with the increase in the distance. It can be seen that the valley effect is non-negligible. The narrower and deeper the valley, the greater the wind pressure effect. (c) When the ratio of the distance between the foot of the mountain and the greenhouse d to the height of the mountain H is less than 5, i.e., d/H < 5, the ratio of the distance to the height has a significant impact on the shape factor of wind load on the greenhouse. When d/H is close to 10, the shape factor of the wind load in the valley area is close to that in the plain area, and the effect of the ratio between the height and the distance is negligible. (d) The proposed calculation model can be used to calculate the effect of mountain height and distance on the shape factor of wind load. The research results can be used in the wind resistance design of plastic greenhouses in valley areas, and can also provide some data support for the revision of the greenhouse structural load code.