Performance and thermoregulatory effects of chronic bupropion administration in the heat

Roelands, Bart; Hasegawa, Hiroshi; Watson, Phillip; Piacentini, Maria Francesca; Buyse, Luk; Schutter, Guido De; Meeusen, Romain

doi:10.1007/s00421-008-0929-x

Cited by 41 publications

(41 citation statements)

References 22 publications

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“…The aim of this and previous studies (Watson et al 2005;Roelands et al 2008aRoelands et al , b, 2009) performed with the same protocol is to elucidate the possible underlying neurotransmitter-governed mechanisms of fatigue and thermoregulation during prolonged exercise in the heat.…”

Section: Discussionmentioning

confidence: 99%

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Time trial performance in normal and high ambient temperature: is there a role for 5-HT?

et al. 2009

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The original central fatigue hypothesis suggested that fatigue during prolonged exercise might be due to higher 5-HT activity. Therefore, we examined the effects of acute administration of a selective 5-HT reuptake inhibitor (SSRI) on performance and thermoregulation. Eleven healthy trained male cyclists completed four experimental trials (two in 18 degrees C, two in 30 degrees C) in a double-blind randomised crossover design. Subjects ingested either a placebo (PLA: lactose 2 x 10 mg) or citalopram (CITAL 2 x 10 mg) on the evening before and the morning of the trial. Subjects cycled for 60 min at 55% W(max), immediately followed by a time trial (TT) to measure performance. The significance level was set at P < 0.05. Acute SSRI did not significantly change performance on the TT (18 degrees C P = 0.518; 30 degrees C P = 0.112). During recovery at 30 degrees C, core temperature was significantly lower in the CITAL trial (P < 0.012). At 30 degrees C heart rate was significantly lower after exercise in CITAL (P = 0.013). CITAL significantly increased cortisol concentrations at rest (P = 0.016), after the TT (P = 0.006) and after 15-min recovery (P = 0.041) at 30 degrees C. 5-HT reuptake inhibition did not cause significant reductions in performance. Core temperature was significantly lower only after the time trial in heat after CITAL administration. The present work failed to prove whether or not 5-HT has an exclusive role in the onset of centrally mediated fatigue during prolonged exercise in both normal and high ambient temperature.

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Section: Discussionmentioning

confidence: 99%

“…The experimental protocol used in this study is identical to the protocol used previously (Watson et al 2005;Roelands et al 2008aRoelands et al , b, 2009, therefore we will address it brieXy. All subjects completed a preliminary maximal exercise test, a familiarization trial and 4 experimental trials.…”

Section: Experimental Protocolmentioning

confidence: 99%

Time trial performance in normal and high ambient temperature: is there a role for 5-HT?

et al. 2009

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“…Therefore, studies with specific effects on either the serotonergic or the dopaminergic systems have been conducted to elucidate the exact influence from either system (169,174,(220)(221)(222). However, in temperate environments a number of exercise studies with human subjects have failed to show any clear performance enhancing effects of elevating extracellular dopamine levels via dopamine reuptake inhibitors or through attempted alterations in cerebral serotonin levels via nutritional or medical manipulations (171,174,221,239,314).…”

Section: Dopaminementioning

confidence: 99%

Performance in the Heat—Physiological Factors of Importance for Hyperthermia‐Induced Fatigue

Nybo

Rasmussen

Sawka

2014

Comprehensive Physiology

272

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This article presents a historical overview and an up-to-date review of hyperthermia-induced fatigue during exercise in the heat. Exercise in the heat is associated with a thermoregulatory burden which mediates cardiovascular challenges and influence the cerebral function, increase the pulmonary ventilation, and alter muscle metabolism; which all potentially may contribute to fatigue and impair the ability to sustain power output during aerobic exercise. For maximal intensity exercise, the performance impairment is clearly influenced by cardiovascular limitations to simultaneously support thermoregulation and oxygen delivery to the active skeletal muscle. In contrast, during submaximal intensity exercise at a fixed intensity, muscle blood flow and oxygen consumption remain unchanged and the potential influence from cardiovascular stressing and/or high skin temperature is not related to decreased oxygen delivery to the skeletal muscles. Regardless, performance is markedly deteriorated and exercise-induced hyperthermia is associated with central fatigue as indicated by impaired ability to sustain maximal muscle activation during sustained contractions. The central fatigue appears to be influenced by neurotransmitter activity of the dopaminergic system, but inhibitory signals from thermoreceptors arising secondary to the elevated core, muscle and skin temperatures and augmented afferent feedback from the increased ventilation and the cardiovascular stressing (perhaps baroreceptor sensing of blood pressure stability) and metabolic alterations within the skeletal muscles are likely all factors of importance for afferent feedback to mediate hyperthermia-induced fatigue during submaximal intensity exercise. Taking all the potential factors into account, we propose an integrative model that may help understanding the interplay among factors, but also acknowledging that the influence from a given factor depends on the exercise hyperthermia situation.

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“…Disturbance of brain homeostasis is difficult to accomplish and previously we clearly indicated that specific physiological reactions can occur, i.e., a marked difference in core temperature. Our previous human studies have shown that influencing dopaminergic re-uptake inhibition in the brain increased rectal temperature (Watson et al 2005;Roelands et al 2008Roelands et al , 2009). Methylphenidate, a potent dopamine reuptake blocker, increased rectal temperature already before the start of exercise in high ambient temperature, without any difference in skin temperature (Roelands et al 2008).…”

mentioning

confidence: 97%

“…This indicates that dopamine is capable of influencing human thermoregulation, without affecting peripheral factors such as skin temperature and sweat rate. Both acute and chronic bupropion administration increased core temperature during exercise in normal and high ambient temperature (Watson et al 2005;Roelands et al 2009). These findings indicate that dopaminergic neurotransmission is indeed able to influence human thermoregulation, presumably by an increased internal heat production.…”

mentioning

confidence: 99%

Caffeine, dopamine and thermoregulation

Roelands

Meeusen

2011

Eur J Appl Physiol

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Performance and thermoregulatory effects of chronic bupropion administration in the heat

Cited by 41 publications

References 22 publications

Time trial performance in normal and high ambient temperature: is there a role for 5-HT?

Time trial performance in normal and high ambient temperature: is there a role for 5-HT?

Performance in the Heat—Physiological Factors of Importance for Hyperthermia‐Induced Fatigue

Caffeine, dopamine and thermoregulation

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