Ninety-six (96) CHI broiler chickens aged 4 weeks were used to determine the effect of Moringa oleifera leaf meal (MOLM) on growth performance and serum biochemical parameters. The 96 broiler chickens were randomly allocated to 4 treatment groups, identified as T1, T2, T3 and T4. Each treatment group consisted of 24 birds replicated 3 times with 8 birds per replicate in a Completely Randomized Design (CRD) with four levels of Moringa leaf meal as treatments. The levels of Moringa leaf meal were 0.00%, 6.00%, 8.00% and 10.00%. Treatment one (T1) which contained no Moringa leaf meal served as the control. The birds in each treatment group were randomly assigned to Moringa leaf meal for 28 days. The birds were fed twice daily, morning and evening. Water was given ad libitum to the birds. The results showed that there were significant differences (P< 0.05) among the treatment groups in final body weight, average daily weight gain, average total weight gain, average total feed intake, average daily feed intake and feed conversion ratio. However, there were no significant differences (P>0.05) among the treatment groups in initial body weight. The results further showed that there were significant differences (P<0.05) among the treatment groups in all the serum biochemical parameters measured: urea, cholesterol, glucose and calcium except Aspartate transaminase which was similar (P>0.05) among the treatment groups. The results of this study indicate that Moringa oleifera leaf meal enhanced growth performance: weight gain, feed intake and feed conversion ratio, in the treated birds compared to the control group with the best result at 8.00% inclusion level. Feeding the birds with MOLM brought about changes in the serum biochemical parameters but without any deleterious effect on them.