Performance characteristics of dedicated molecular breast imaging systems at low doses

Long, Zaiyang; Conners, Amy Lynn; Hunt, Katie N.; Hruska, Carrie B.; O’Connor, Michael K.

doi:10.1118/1.4950873

Cited by 18 publications

(38 citation statements)

References 27 publications

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“…Molecular breast imaging (MBI) uses a small dual‐headed semiconductor‐based gamma camera in a mammographic configuration to obtain high‐resolution functional images of 99m Tc‐sestamibi uptake in the breast . Modern MBI systems use pixelated solid‐state cadmium zinc telluride (CZT) detector array optimized for near‐field imaging with collimator septa matched to pixel spacing yielding superior spatial resolution and sensitivity compared with conventional gamma cameras . The MBI examination typically involves an intravenous administration of 99m Tc‐sestamibi, with imaging commencing roughly 5 min after injection.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Modern MBI systems use pixelated solid-state cadmium zinc telluride (CZT) detector array optimized for near-field imaging with collimator septa matched to pixel spacing yielding superior spatial resolution and sensitivity compared with conventional gamma cameras. 4,5 The MBI examination typically involves an intravenous administration of 99m Tc-sestamibi, with imaging commencing roughly 5 min after injection. The patient's breast is placed directly onto one detector head, while the other detector is lowered until light compression (~15 lbs.)…”

Section: Introductionmentioning

confidence: 99%

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Quantitation of tumor uptake with molecular breast imaging

Bache

Kappadath

2017

Medical Physics

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Using DEW scatter- and our Volumetric GM attenuation-correction methodology yielded accurate estimates of tumor counts in MBI over various tumor sizes, shapes, depths, background uptake, and compressed breast thicknesses. Accurate tumor uptake can be converted to radiotracer uptake concentration, allowing three patient-specific metrics to be calculated for quantifying absolute uptake and relative uptake change for assessment of treatment response.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitation of tumor uptake with molecular breast imaging

Bache

Kappadath

2017

Medical Physics

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“…Over the last 20 years, research has demonstrated the value of compact high resolution gamma cameras for dedicated nuclear medicine breast imaging as a means of mitigating the lack of resolution and sensitivity of standard large cameras 1–5 . Three main types of gamma cameras are currently being implemented: scintillation cameras with position sensitive photomultiplier tubes (PSPMTs) for PET and SPECT, scintillation cameras using silicon photomultipliers (SiPMs) for PET, and solid state direct-conversion semiconductor cameras for PET and SPECT.…”

Section: Introductionmentioning

confidence: 99%

“…The most commonly used solid-state semiconductor is cadmium zinc telluride (CZT). CZT arrays exhibit good gamma ray detection efficiency and have been shown to have very good energy resolution 5,10–12 , but suffer from low energy tailing due to hole trapping. CZT systems are currently available from a small number of sources at a great cost for low-defect samples.…”

Section: Introductionmentioning

confidence: 99%

Design and characterization of a low profile NaI(Tl) gamma camera for dedicated molecular breast tomosynthesis

et al. 2016

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A new low profile gamma camera is being developed for use in a dual modality (x-ray transmission and gamma-ray emission) tomosynthesis system. Compared to the system’s current gamma camera, the new camera has a larger field of view (~20×25 cm) to better match the system’s x-ray detector (~23×29 cm), and is thinner (7.3 cm instead of 10.3 cm) permitting easier camera positioning near the top surface of the breast. It contains a pixelated NaI(Tl) array with a crystal pitch of 2.2 mm, which is optically coupled to a 4×5 array of Hamamatsu H8500C position sensitive photomultiplier tubes (PSPMTs). The manufacturer-provided connector board of each PSPMT was replaced with a custom designed board that a) reduces the 64 channel readout of the 8×8 electrode anode of the H8500C to 16 channels (8X and 8Y), b) performs gain non-uniformity correction, and c) reduces the height of the PSPMT-base assembly, 37.7 mm to 27.87 mm. The X and Y outputs of each module are connected in a lattice framework, and at two edges of this lattice, the X and Y outputs (32Y by 40X) are coupled to an amplifier/output board whose signals are fed via shielded ribbon cables to external ADCs. The camera uses parallel hole collimation. We describe the measured camera imaging performance, including intrinsic and extrinsic spatial resolution, detection sensitivity, uniformity of response, energy resolution for 140 keV gamma rays, and geometric linearity.

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“…Some dedicated MBI detectors comprise pixelated arrays of sodium iodide coupled to position-sensitive photomultiplier tubes (also known as breast-specific g-imaging (2)). Other detector configurations include a multicrystal array of cesium iodide coupled to solid-state silicon photodiodes (3) and a completely solid-state detector that uses cadmium-zinc-telluride (2). Collimators for MBI systems can vary in design.…”

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confidence: 99%

Guidelines for Quality Control Testing of Molecular Breast Imaging Systems

Nardinger

Tran

Swanson

et al. 2018

J. Nucl. Med. Technol.

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Molecular breast imaging (MBI) is a nuclear medicine test that uses dedicated γ-cameras designed for imaging of the breast. Despite growing adoption of MBI, there is currently a lack of guidance on appropriate quality control procedures for MBI systems. Tests designed for conventional γ-cameras either do not apply or must be modified for dedicated detectors. Our objective was to provide practical guidance for physics testing of MBI systems by adapting existing quality control procedures for conventional systems. Quality control tests designed for conventional γ-cameras were attempted on a dedicated MBI system and then modified as necessary to accommodate the pixelated detector, limited space between dual-detector heads, and inability to fully rotate the detector gantry. MBI systems were found to warrant quality control testing of uniformity, spatial resolution, count sensitivity, energy resolution, and lesion contrast. The modified procedures and special considerations needed for these tests were investigated and described. Physics tests of intrinsic uniformity, count rate parameters, and overall system performance for SPECT did not apply to dedicated MBI systems. Routine physics testing of dedicated MBI equipment is important for verifying system specifications and monitoring changes in performance. As adoption of MBI grows, routine testing may be required for obtaining and maintaining accreditation from regulatory bodies.

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Performance characteristics of dedicated molecular breast imaging systems at low doses

Cited by 18 publications

References 27 publications

Quantitation of tumor uptake with molecular breast imaging

Quantitation of tumor uptake with molecular breast imaging

Design and characterization of a low profile NaI(Tl) gamma camera for dedicated molecular breast tomosynthesis

Guidelines for Quality Control Testing of Molecular Breast Imaging Systems

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