The results of an experimental investigation on pressure drop and heat transfer in spacer-filled plane channels, which are representative of Membrane Distillation units, are presented and discussed. Local and mean heat transfer coefficients were obtained by using Thermochromic Liquid Crystals and Digital Image Processing. The performances of a novel spacer geometry, consisting of spheres that are connected by cylindrical rods, and are hereafter named spheres spacers, were compared with those of more conventional woven and overlapped spacers at equal values of the Reynolds number Re (in the range ~150 to ~2500), the pitch-to-channel height ratio, the flow attack angle and the thermal boundary conditions (two-side heat transfer). For any flow rate, the novel spacer geometry provided the least friction coefficient and a mean Nusselt number intermediate between those of the overlapped and the woven spacers. For any pressure drop and for any pumping power, the novel spacer provided the highest mean Nusselt number over the whole Reynolds number range that was investigated. The influence of buoyancy was also assessed for the case of the horizontal channels. Under the experimental conditions (channel height H â 1 cm, ÎT â 10 °C), it was found to be large in empty (spacer-less) channels that were up to Re â 1200 (corresponding to a Richardson number Ri of ~0.1), but it was much smaller and limited to the range Re < ~500 (Ri < ~0.5) in the spacer-filled channels.