2019
DOI: 10.1016/j.jpha.2019.03.002
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Performance comparison of chlorinated chiral stationary phases in supercritical fluid chromatography for separation of selected pyrrolidone derivatives

Abstract: The effects of two chlorinated chiral stationary phases, namely, Lux Cellulose-2 and Lux i-Cellulose-5, flow-rate, percentage of co-solvent and chemical structures of the compounds on retention and resolution were studied within this article. In this work a backpressure of 150 bar, a temperature of 40 °C and 10% of methanol as co-solvent were chosen as operating conditions. The optimum flow-rate was 2 mL/min. The percentage of co-solvent was studied between 7.5% and 15%. We have observed that 15% of methanol g… Show more

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Cited by 4 publications
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“…Although SFC separations on the latter CSP have been reported [35,36,37], to the best of our knowledge this is the first comparison involving i-Amylose-3. Our results suggest halogen- and hydrogen-bonding to be significant for chiral recognition of chlorinated analytes such as K and its metabolites on chlorinated polysaccharide-based CSPs, which is supported by previous observations concerning achiral chemo-selectivity of halogenated analytes on Amylose-2 [38].…”
Section: Discussionmentioning
confidence: 99%
“…Although SFC separations on the latter CSP have been reported [35,36,37], to the best of our knowledge this is the first comparison involving i-Amylose-3. Our results suggest halogen- and hydrogen-bonding to be significant for chiral recognition of chlorinated analytes such as K and its metabolites on chlorinated polysaccharide-based CSPs, which is supported by previous observations concerning achiral chemo-selectivity of halogenated analytes on Amylose-2 [38].…”
Section: Discussionmentioning
confidence: 99%