A good orthogonality is provided by the wavelet-based orthogonality frequency division multiplexing (W-OFDM) and well reduction of bit error rate is gained with W-OFDM over conventional OFDM systems. Most importantly, it provides enhanced spectral efficiency since it does not require cyclic prefix (CP) which leads to the achievement of ultra-high data rates. Hence, this can be used in 5 th generation (5G) wireless communication networks. It is proposed to use the discrete wavelet transform (DWT) based OFDM in place of conventional discrete fourier transform (DFT) based OFDM in the applications of long term evaluation (LTE). However, discrete wavelet transforms (DWT) based OFDM system suffers from the down sampling, which mitigates the actual size of input bit streams and there by degradation in the system efficiency. To resolve this issue, and for enhancing further mitigation in bit error rate (BER) performance, a novel W-OFDM is proposed. Our proposed W-OFDM system utilizes translation invariant wavelet transform (TIWT) in place of DWT for enhanced spectral efficiency. In addition, fading channel environment is considered to disclose the effectiveness of proposed TIWT-OFDM system. Extensive experimental results show that the BER performance of proposed TIWT-OFDM is superior to the existing OFDM systems like DFT-OFDM and DWT-OFDM systems.