Performance Comparison of the <i>artus</i> HBV QS-RGQ and the CAP/CTM HBV v2.0 Assays regarding Hepatitis B Virus DNA Quantification

Madihi, Salma; Syed, Hashim; Lazar, Fatiha; Zyad, Abdelmajid; Benani, Abdelouaheb

doi:10.1155/2020/4159189

Cited by 2 publications

(1 citation statement)

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“…To our knowledge, the level of HBV DNA acts as a direct, specific, and sensitive indicator for HBV infection. It constitutes an important reference for diagnosis, treatment, and assessment of the condition in patients with HBV-related ailments[ 22 ]. Previous studies have underscored the common occurrence of HBV reactivation in patients diagnosed with HBV-related HCC undergoing partial hepatectomy[ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Association of preoperative antiviral treatment with incidences of post-hepatectomy liver failure in hepatitis B virus-related hepatocellular carcinoma

Wang,

Lin,

Zhou

et al. 2024

World J Gastrointest Surg

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BACKGROUND Post-hepatectomy liver failure (PHLF) is a common consequence of radical partial hepatectomy in hepatocellular carcinoma (HCC). AIMS To investigate the relationship between preoperative antiviral therapy and PHLF, as well as assess the potential efficacy of hepatitis B virus (HBV) DNA level in predicting PHLF. METHODS A retrospective study was performed involving 1301 HCC patients with HBV who underwent radical hepatectomy. Receiver operating characteristic (ROC) analysis was used to assess the capacity of HBV DNA to predict PHLF and establish the optimal cutoff value for subsequent analyses. Logistic regression analyses were performed to assess the independent risk factors of PHLF. The increase in the area under the ROC curve, categorical net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to quantify the efficacy of HBV DNA level for predicting PHLF. The P < 0.05 was considered statistically significant. RESULTS Logistic regression analyses showed that preoperative antiviral therapy was independently associated with a reduced risk of PHLF (P < 0.05). HBV DNA level with an optimal cutoff value of 269 IU/mL (P < 0.001) was an independent risk factor of PHLF. All the reference models by adding the variable of HBV DNA level had an improvement in area under the curve, categorical NRI, and IDI, particularly for the fibrosis-4 model, with values of 0.729 (95%CI: 0.705-0.754), 1.382 (95%CI: 1.341-1.423), and 0.112 (95%CI: 0.110-0.114), respectively. All the above findings were statistically significant. CONCLUSION In summary, preoperative antiviral treatment can reduce the incidence of PHLF, whereas an increased preoperative HBV DNA level has a correlative relationship with an increased susceptibility to PHLF.

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Section: Introductionmentioning

confidence: 99%