Performance du dosage de PSA dans le dépistage précoce du cancer de la prostate (étude cas–témoins dans un hôpital de l’Ouest algérien)

Berroukche, Abdelkrim; Bendahmane, Malika; Kandouci, Baderdine Abdelkrim

doi:10.1016/j.immbio.2012.01.010

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…The percentage of patient with PSA level > 20 ng/ml, remains above that found by other authors, in particular those of Saida's city (43.6%) (11) and that of Oran's city (46%) (12). These data may pose the problem of delayed diagnosis of prostate cancer in Tlemcen.…”

Section: Discussionmentioning

confidence: 55%

Epidemiological and Genetical Profile of Prostate Cancer Cases in Tlemcen, West Algeria

Moqaddem¹,

Aouar²,

Kazi-Tani³

et al. 2019

Acta HealthMedica

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Background: According to WHO, prostate cancer is the second most frequent cancer in men. Prostate cancer is a complex, multifactorial disease with genetic and environmental factors involved in its etiology. The age, family history and the ethno-racial background are the strongest risk factors for prostate cancer. Objective: To study the epidemiological, genetical and clinical aspects of prostate cancer in Tlemcen's population. Methods: We made a cross-sectional study on 184 patients with prostate cancer received at the Urology Division of Tlemcen's teaching hospital, from 2011 to 2016, resident in Tlemcen's city. The collected information included the age at diagnosis, the geographical location, family history of cancer, Prostate-specific antigen (PSA) level and Gleason score on biopsy. Results: The median age of our patients was 73 years with extremes between 53 and 7 years. The most frequent age group was 70-80 years with 50% of the total sample of 184 cases. Seventy-four percent of patients have a very high PSA level (higher than 20 ng/ml). Thirty-two percent of the cases have a highly aggressive cancer, and 66% with moderately aggressive cancer. The examination of family history shows that 37% of patients had family history of cancer, 45% of whom are prostate cancer. The inherited form of prostate cancer is noticed in 4.9% of cases. Conclusion: This study raises a number of questions, considering the high number of family history noticed in this study, and suggests the existence of genetic determinants, and the interactions gene-environment influencing the genesis of this cancer. An earlier diagnosis is essential, according to these data, especially for men at a "high risk" of this cancer, which will constitute an essential tool for more effective anti-cancer strategy.

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Section: Discussionmentioning

confidence: 55%

Epidemiological and Genetical Profile of Prostate Cancer Cases in Tlemcen, West Algeria

Moqaddem¹,

Aouar²,

Kazi-Tani³

et al. 2019

Acta HealthMedica

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Biological and Pathological Study of Prostate Cancer at Localized Stage in Western Algeria

Berroukche

2013

J. Anal. Oncol.

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Objective:Toshow the contribution of the pathological examination, associated with prostatic specific antigen (PSA), in the early detection of prostate cancer in Western Algeria. Methodology:This study focused on 160 cases, old between 50-80 years, with histologically confirmed prostate adenocarcinoma and carried out in urology hospitals in western Algeria during the period from 2007 to 2011. Tumor stage, PSA, Gleason score and the degree of tumor differentiation were analyzed. Results:135 patients, with a poor prognosis and a Gleason score > 8 index of incurable malignant aggression, have not been the subject of this study. But the other 35 patients were candidates because they had a favorable prognosis with a localized stage that could be curable. Gleason score was between 5-6 in 5 patients with TPSA 10 ng / ml at differential stage, score of 7 in 10 patients with TPSA between 10-20 ng / ml atmoderately differentiated stage and finally a score of 8 in 20 patients with TPSA between 20,1-50 ng / ml at apoorly differentiated stage. Conclusion:There is a strong correlation between TPSA, Gleason score and the degree of tumor differentiation. Biological and pathological prognosis, established early, can reduce tumor progression.

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Performance du dosage de PSA dans le dépistage précoce du cancer de la prostate (étude cas–témoins dans un hôpital de l’Ouest algérien)

Cited by 2 publications

References 11 publications

Epidemiological and Genetical Profile of Prostate Cancer Cases in Tlemcen, West Algeria

Epidemiological and Genetical Profile of Prostate Cancer Cases in Tlemcen, West Algeria

Biological and Pathological Study of Prostate Cancer at Localized Stage in Western Algeria

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