The authors theoretically designed a highly sensitive SPR biosensor with a hybrid structure using two‐dimensional nanomaterials (BP‐WS2). Using the transfer matrix method (TMM), the performance of the sensor in terms of reflection, sensitivity, detection accuracy, and quality factor is investigated, and by changing the structural parameters of the sensor, the obtained results are further analysed so that an optimal structure with optimal performance can be achieved. The sensor was optimised with four layers of BP and a single layer of WS2. This composite structure is placed on a 50 nm thick gold layer and concluded with a maximum sensitivity of 234 deg/RIU with a FOM of 26.53 RIU−1. This biosensor is designed by considering the advantages and characteristics of biosensors in their resistance and high electrical properties, as well as the ability to detect diseases quickly.