The yearning to win sports competitions has led some athletes to dope. Doping in sports is a real threat to the ‘Spirit of Sport’ and fairness. The pharmacokinetics of performance-enhancing drugs differ, as do their effects and purposes of use. As one of the most effective and decisive solutions, the idea to issue a prohibited list came to raise the legal awareness level among athletes about the types of prohibited substances and methods they have to avoid and in which time specifically. In addition, for the sake of broader and more comprehensive cooperation between the law, medicine, and pharmacology, to confront the phenomenon, and limit it to the narrowest possible scope on the other hand. The idea to issue the prohibited list came. Historical, descriptive, and legal approaches are employed in conducting this review. Additionally, the method of conceptual analysis is used to discover the exact normative terminology. The most significant finding for this review is that the issuance of the Prohibited List brought greater stability to sporting events. Its annual issuance is legal proof in front of everyone (countries, international sports organisations, and athletes).