Performance evaluation and optimization of the MiniPET-II scanner

Lajtos, Imre; Emri, Miklós; Kis, Sándor Attila; Opposits, Gábor; Pótári, Norbert; Király, B.; Nagy, Ferenc; Trón, Lajos; Balkay, László

doi:10.1016/j.nima.2012.12.079

Cited by 11 publications

(15 citation statements)

References 23 publications

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“…Stitches were put in the wound and the tumors were allowed to grow until 1.4-1.6 cm 3 and in vivo experiments were carried out. min after tracer injection animals were anaesthetized by 3% isoflurane with a dedicated small animal anesthesia device and whole body PET scans (10-min static PET scans at each bed position) were acquired using the MiniPET-II small animal PET scanner (Lajtos et al, 2013). …”

Section: Tumor Modelsmentioning

confidence: 99%

In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer 68Ga-NOTA-c(NGR)

Máté

Kertész

Enyedi

et al. 2015

European Journal of Pharmaceutical Sciences

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Purpose: Aminopeptidase N (APN/CD13) plays an important role in tumor neoangiogenic process and the development of metastases. Furthermore, it may serve as a potential target for cancer diagnosis and therapy. Previous studies have already shown that asparagine-glycinearginine (NGR) peptides specifically bind to APN/CD13. The aim of the study was to synthesize and investigate the APN/CD13 specificity of a novel 68

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Section: Tumor Modelsmentioning

confidence: 99%

In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer 68Ga-NOTA-c(NGR)

Máté

Kertész

Enyedi

et al. 2015

European Journal of Pharmaceutical Sciences

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“…Thereafter the samples were washed twice at room temperature. Following that 2 ml gl-DMEM was added to each sample and the 18 FDG uptake was determined by the MiniPET-II scanner (Lajtos et al, 2013). 2 min acquisition time was used.…”

Section: In Vitro 18 Fdg Uptake and Efflux Of Cancer Cells Measured Imentioning

confidence: 99%

18FDG a PET tumor diagnostic tracer is not a substrate of the ABC transporter P-glycoprotein

Krasznai

Trencsényi

Mikecz

et al. 2014

European Journal of Pharmaceutical Sciences

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“…where S A,i is the absolute sensitivity at slice i and n is the maximal slice index (35 in our case) (12). This formula follows the concept of some recent articles (12,16,17) and the extension of the NEMA NU-4 in 2011.…”

Section: Sensitivitymentioning

confidence: 95%

“…For the MiniPET-2, the PMTs were attached to the lutetium-yttrium oxyorthosilicate scintillation crystal matrixes with V-788 optical coupling compound (Visilox Systems, Inc.); the thickness of the optical coupling remained under 0.5 mm. Digital signals were fed into a Virtex4 (Xilinx Inc.) field-programmable gate array board, where time stamp generation, energy calculation, signal recognition, and status checking took place (12). Data from the detector modules were transmitted to the data acquisition computer via a 100BASE-TX ethernet network.…”

Section: System Descriptionmentioning

confidence: 99%

“…In addition, we calculated a parameter similar to noiseequivalent counting rate (NEC) defined as true 2 /[true 1 (2 · random)], which was used to find the optimal t-value. For the MiniPET-2, the optimal t-value was determined in a previous study (12). Each detector module is in coincidence with 3 other modules on the opposite side of the gantry.…”

Section: Optimization Of Coincidence Time Window (τ-Value)mentioning

confidence: 99%

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A Promising Future: Comparable Imaging Capability of MRI-Compatible Silicon Photomultiplier and Conventional Photosensor Preclinical PET Systems

et al. 2015

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We recently completed construction of a small-animal PET systemthe MiniPET-3-that uses state-of-the-art silicon photomultiplier (SiPM) photosensors, making possible dual-modality imaging with MRI. In this article, we compare the MiniPET-3 with the MiniPET-2, a system with the same crystal geometry but conventional photomultiplier tubes (PMTs). Methods: The standard measurements proposed by the National Electrical Manufacturers Association NU 4 protocols were performed on both systems. These measurements included spatial resolution, system sensitivity, energy resolution, counting rate performance, scatter fraction, spillover ratio for air and water, recovery coefficient, and image uniformity. The energy windows were set to 350-650 keV on the MiniPET-2 and 360-662 keV on the MiniPET-3. Results: Spatial resolution was approximately 17% better on average for the MiniPET-3 than the MiniPET-2. The systems performed similarly in terms of peak absolute sensitivity (∼1.37%), spillover ratio for air (∼0.15), spillover ratio for water (∼0.25), and recovery coefficient (∼0.33, 0.59, 0.81, 0.89, and 0.94). Uniformity was 5.59% for the MiniPET-2 and 6.49% for the MiniPET-3. Minor differences were found in scatter fraction. With the ratlike phantom, the peak noise-equivalent counting rate was 14 kcps on the MiniPET-2 but 24 kcps on the MiniPET-3. However, with the mouselike phantom, these values were 55 and 91 kcps, respectively. The optimal coincidence time window was 6 ns for the MiniPET-2 and 8 ns for the MiniPET-3. Conclusion: Images obtained with the SiPM-based Mini-PET-3 small-animal PET system are similar in quality to those obtained with the conventional PMT-based MiniPET-2.Key Words: MiniPET; small-animal PET scanner; performance evaluation; instrumentation; molecular imaging J Nucl Med 2015; 56:1948 56: -1953 56: DOI: 10.2967 Ef forts to integrate PET and MRI have advanced significantly in recent years, fostered mainly by new photosensor technologies (1-4). Conventional photomultiplier tube (PMT) detectors benefit from high signal gain in the range of 10 5 -10 7 (5,6). Low noise and fast transit time (;100 ps) are also available today and have made PMTs the first candidate for applications involving time-of-flight PET technology. In addition, PMTs have lower noise than avalanche photodiode or silicon photomultiplier (SiPM) detectors (5). However, in strong magnetic fields PMTs cannot produce position maps that are acceptable for imaging purposes. In contrast, avalanche photodiodes can be used efficiently as a photosensor for PET when near strong magnets. Some successful approaches using avalanche photodiodes have already been introduced for combined PET/MRI applications (2,7,8). However, avalanche photodiodes have significantly higher rise times than PMTs (up to 2-3 ns) (5), preventing the timing resolution from being adequate for time-of-flight PET. The low gain (;10 2 ) is also a disadvantage of avalanche photodiodes (2,5).By coupling lutetium oxyorthosilicate crystals with new SiPM technology, a timing resolutio...

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Performance evaluation and optimization of the MiniPET-II scanner

Cited by 11 publications

References 23 publications

In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer 68Ga-NOTA-c(NGR)

In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer 68Ga-NOTA-c(NGR)

18FDG a PET tumor diagnostic tracer is not a substrate of the ABC transporter P-glycoprotein

A Promising Future: Comparable Imaging Capability of MRI-Compatible Silicon Photomultiplier and Conventional Photosensor Preclinical PET Systems

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