The performance of a laboratory-scale sewage treatment system composed of an up-flow anaerobic sludge blanket (UASB) reactor and a moving bed biofilm reactor (MBBR) at a temperature of (22-35°C) was evaluated. The entire treatment system was operated at different hydraulic retention times (HRT's) of 13.3, 10 and 5.0 h. An overall reduction of 80-86% for COD total ; 51-73% for COD colloidal and 20-55% for COD soluble was found at a total HRT of 5-10 h, respectively. By prolonging the HRT to 13.3 h, the removal efficiencies of COD total , COD colloidal and COD soluble increased up to 92, 89 and 80%, respectively. However, the removal efficiency of COD suspended in the combined system remained unaffected when increasing the total HRT from 5 to 10 h and from 10 to 13.3 h. This indicates that, the removal of COD suspended was independent on the imposed HRT. Ammonia-nitrogen removal in MBBR treating UASB reactor effluent was significantly influenced by organic loading rate (OLR). 62% of ammonia was eliminated at OLR of 4.6 g COD m -2 day -1 . The removal efficiency was decreased by a value of 34 and 43% at a higher OLR's of 7.4 and 17.8 g COD m -2 day -1 , respectively. The mean overall residual counts of faecal coliform in the final effluent were 8.9 9 10 4 MPN per 100 ml at a HRT of 13.3 h, 4.9 9 10 5 MPN per 100 ml at a HRT of 10 h and 9.4 9 10 5 MPN per 100 ml at a HRT of 5.0 h, corresponding to overall log 10 reduction of 2.3, 1.4 and 0.7, respectively. The discharged sludge from UASB-MBBR exerts an excellent settling property. Moreover, the mean value of the net sludge yield was only 6% in UASB reactor and 7% in the MBBR of the total influent COD at a total HRT of 13.3 h. Accordingly, the use of the combined UASB-MBBR system for sewage treatment is recommended at a total HRT of 13.3 h.