Polymer matrix composites (PMC), often referred to as fiber reinforced plastics (FRP), consist of fiber reinforcement (E-glass, S2glass, aramid, carbon, or natural fibers) and polymer matrix/resin (polyester, vinyl ester, polyurethane, phenolic, and epoxies). Eglass/polyester and E-glass/vinyl ester composites are extensively used in the marine, sports, transportation, military, and construction industries. These industries primarily use low-cost open molding processes, such as manual/spray lay-up. Polyester and vinyl ester resin systems produce styrene emissions. Because of the stringent EPA regulations on styrene emissions, composite manufacturers are interested in using low-cost closed molding processes, such as vacuum-assisted resin transfer molding (VARTM) and styrene-free resin systems such as non-foam and full-density polyurethanes (PUR). Polyurethanes are polymers created by addition of polyisocyanates and polyols. The polyol component in polyurerhane can be produced from soybean oil. This study demonstrates that with the proper addition of nanoparticles, mechanical properties of soy-based polyurethane can be enhanced. These nanomodified soy-based polyurethane/glass composites manufactured by using the low-cost VARTM process provide alternatives to traditional glass/polyester and glass/vinyl ester composites. These composites will be more environmental friendly for two reasons: (a) Polyurethane does not produce styrene emission, thereby, resulting in a safer work place and (b) Polyol is made from a renewable resource (soybean oil).