Performance evaluation of the eXplore speCZT preclinical imaging system

Matsunari, Ichiro; Miyazaki, Yoshiharu; Kobayashi, Masato; Nishi, Kodai; Mizutani, Asuka; Kawai, Keiichi; Hayashi, Akiko; Komatsu, Ryoko; Yonezawa, Shoko; Kinuya, Seigo

doi:10.1007/s12149-014-0828-7

Cited by 17 publications

(13 citation statements)

References 18 publications

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“…All acquisitions were performed using the eXplore speCZT (GE Healthcare, Milwaukee, WI, USA) preclinical SPECT system. Its characteristics and performance have been reported in detail previously [ 5 ]. Briefly, this system has a stationary detector with interchangeable rotating collimators.…”

Section: Methodsmentioning

confidence: 99%

“…We used two collimators dedicated for rat imaging; a standard (STD) five-pinhole collimator and custom-made high-sensitivity (HS) five-pinhole collimator, which was available on request from TriFoil Imaging, Inc. (Northridge, CA, USA). The characteristics of STD have been described previously [ 5 ]. In brief, it has five pinholes of 1 mm in diameter and bore of 89 mm in diameter with radius of rotation/focal length of 50/70 mm.…”

Section: Methodsmentioning

confidence: 99%

“…Preclinical molecular imaging such as single-photon emission computed tomography (SPECT) and positron emission tomography (PET) using small animals is increasingly being recognized as an important tool for cardiovascular research [ 1 , 2 ]. In particular, SPECT equipped with multi-pinhole collimators enables small-animal imaging with high spatial resolution and reasonable sensitivity [ 3 - 5 ]. In this context, there are a number of studies that used preclinical SPECT to assess myocardial perfusion in rodents [ 6 - 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…It is important to note, however, that high image quality is essential for reliable measurements of myocardial images using such a preclinical SPECT system. Furthermore, the image quality is likely to be affected by many factors such as injection dose [ 11 ], reconstruction settings [ 5 , 11 ], post-reconstruction filtering [ 11 ], and collimator choice [ 12 ]. In clinical myocardial perfusion imaging studies, there is an increasing body of evidence that a newer generation cadmium-zinc telluride (CZT)-based SPECT camera equipped with multi-pinhole collimators provides high image quality and thereby high diagnostic performance even when injection dose is low [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of injection dose, post-reconstruction filtering, and collimator choice on image quality of myocardial perfusion SPECT using cadmium-zinc telluride detectors in the rat

Mizutani

Matsunari²,

Kobayashi

et al. 2015

EJNMMI Phys

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BackgroundThe aims of this study were (1) to evaluate the impact of injection dose, post-reconstruction filtering, and collimator choice on image quality of myocardial perfusion single-photon emission computed tomography (SPECT) using cadmium-zinc telluride (CZT) detectors and (2) to determine how these factors affect measured infarct size in the in vivo rat.MethodsTwenty-four healthy and eight myocardial infarct (MI) rats underwent myocardial perfusion SPECT imaging after injection of various doses (25 to 200 MBq) of 99mTc-tetrofosmin using a standard (STD) five-pinhole collimator and high-sensitivity (HS) five-pinhole collimator. Image quality score, contrast-to-noise ratio, sharpness index, coefficient of variation (CV), and measured defect size were assessed as measures of image quality.ResultsThe image quality score increased and CV decreased as a function of injection dose. The contrast-to-noise ratio increased and sharpness index decreased as a function of Gaussian kernel size. When STD and HS were compared, HS tended to show higher image quality score and lower CV than STD. The use of post-reconstruction filter significantly improved image quality score and lessened CV. The reproducibility of defect size measurements, as assessed by intraclass correlation coefficients (ICC), between the collimators was poor-to-moderate (ICC = −0.31~0.57) with low (25 MBq) injection dose and with no or light (1.5-mm kernel size) filtering, whereas it was good-to-excellent (ICC = 0.75~0.97) with high (200 MBq) dose or low dose with heavy (2.5-mm kernel size) filtering. The filtering-related reproducibility was poor (ICC = −0.18~0.17) for STD with low injection dose, whereas it was good-to-excellent (ICC = 0.79~0.89) for HS. Furthermore, there was a filtering-related underestimation of defect size particularly with the use of heavy smoothing.ConclusionsAppropriate imaging setting is important to obtain high quality images and thereby reliable measurements using a preclinical myocardial SPECT in the rat. When only a low injection dose (25 MBq) is allowed, we would recommend to use HS with light (1.5-mm kernel size) filtering.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of injection dose, post-reconstruction filtering, and collimator choice on image quality of myocardial perfusion SPECT using cadmium-zinc telluride detectors in the rat

Mizutani

Matsunari²,

Kobayashi

et al. 2015

EJNMMI Phys

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“…In this regard, micro PET imaging offers much higher sensitivity and is more suitable to reduce radiation exposure, although its limited spatial resolution (* 0.7 mm in FWHM) as compared to the state-of-the-art micro-SPECT system (0.35 mm) may be an issue. 11 Alternatively, newer generation cadmium zinc telluride (CZT)-based micro-SPECT systems 12 may be an option for low dose imaging as indicated in clinical studies. 13,14 3.…”

mentioning

confidence: 99%

Microvascular function measurement in mice: From large to small

Matsunari

2021

Journal of Nuclear Cardiology

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CdTe XG‐Cam: A new high‐resolution x‐ray and gamma‐ray camera for studies of the pharmacokinetics of radiopharmaceuticals in small animals

Katsuragawa,

Yagishita,

Takeda

et al. 2024

Medical Physics

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BackgroundThe recent emergence of targeted radionuclide therapy has increased the demand for imagers capable of visualizing pharmacokinetics in developing radiopharmaceuticals in the preclinical phase. Some radionuclides emit hard x‐rays and gamma‐rays below 100 keV, in which energy range the performance of conventional NaI scintillators is poor. Multipinhole collimators are also used for small animal imaging with a good spatial resolution but have a limited field of view (FOV).PurposeIn this study, a new imager with high sensitivity over a wide FOV in the low‐energy band (100 keV) was developed for the pharmacokinetic study.MethodsWe developed an x‐ray and gamma‐ray camera for high‐resolution spectroscopy, named “CdTe XG‐Cam,” equipped with a cadmium telluride semiconductor detector and a parallel‐hole collimator using a metal 3D printer. To evaluate the camera‐system performance, phantom measurements with single and dual nuclides (, , and were performed. The performance for in vivo imaging was evaluated using tumor‐bearing mice to which a nuclide ( or administered.ResultsWe simultaneously obtained information on and , which emit emission lines in the low‐energy band with peak energies close to each other (23–26 keV for and 27–31 keV for , and applied an analytical method based on spectral model fitting to determine the individual radioactivities accurately. In the small animal imaging, the distributions of the nuclide in tumors were accurately quantified and time‐activity curves in tumors are obtained.ConclusionsThe demonstrated capability of our system to perform in vivo imaging suggests that the camera can be used for applications of pharmacokinetics research.

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Performance evaluation of the eXplore speCZT preclinical imaging system

Abstract: The overall performance shows that the eXplore speCZT system is suitable for preclinical imaging-based research using small-animals.

Cited by 17 publications

References 18 publications

Impact of injection dose, post-reconstruction filtering, and collimator choice on image quality of myocardial perfusion SPECT using cadmium-zinc telluride detectors in the rat

Impact of injection dose, post-reconstruction filtering, and collimator choice on image quality of myocardial perfusion SPECT using cadmium-zinc telluride detectors in the rat

Microvascular function measurement in mice: From large to small

CdTe XG‐Cam: A new high‐resolution x‐ray and gamma‐ray camera for studies of the pharmacokinetics of radiopharmaceuticals in small animals

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