Performance evaluation of the LabPET12, a large axial FOV APD-based digital PET scanner

Bergeron, Mélanie; Cadorette, J.; Bureau-Oxton, Chloe; Tetrault, M.-A.; Leroux, J.-D.; Lepage, Martin; Robert, G.; Fontaine, R.

doi:10.1109/nssmic.2009.5401915

Cited by 15 publications

(19 citation statements)

References 13 publications

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“…The application of the protocol to the assessment of doxorubicin cardiotoxicity was performed on a LabPET4 scanner [15,16] with a transaxial and axial field of view (FOV) of 11 cm and 3.75 cm, respectively, and a nearly isotropic resolution of 1.35 mm. The LabPET4 scanner was used in these latter experiments as it replaced the older Sherbrooke small animal PET scanner.…”

Section: Pet Imagingmentioning

confidence: 99%

[11C]Acetate rest–stress protocol to assess myocardial perfusion and oxygen consumption reserve in a model of congestive heart failure in rats

Croteau¹,

Gascon²,

Bentourkia³

et al. 2012

Nuclear Medicine and Biology

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This study describes an [ 11 C]acetate rest/stress method to obtain an indirect estimate of myocardial blood flow (MBF) and myocardial oxygen consumption (MVO 2 ) in rats. Doxorubicin cardiotoxicity was used to test the usefulness of this approach for the assessment of congestive heart failure. Methods-[11 C]acetate rest-stress have been used in clinical research to assess the capacity of the coronary arteries to respond to stress. In this article we used this approach to assess the cardiotoxicity of doxorubicin in a rat model. The method was first validated in a group of healthy rats and then used to follow the effect of doxorubicin chemotherapy on cardiac function. The effect of doxorubicin on myocardial perfusion and oxygen consumption reserve was measured at rest and under dobutamine stimulation.Results-Validation of the protocol showed a good correlation between the MBF and MVO 2 (r 2 = 0.68). The doxorubicin treated group showed a significant (p=0.04) decrease in cardiovascular perfusion reserve at 1.3 ± 0.2 compared to the control animals at 1.6 ± 0.2. Similar results were obtained for the myocardial oxygen consumption reserve (treated 1.8 ± 0.4 vs controls 2.3 ± 0.3; p=0.02).Conclusions-We describe an [ 11 C]acetate PET rest/stress protocol for the assessment of cardiotoxicity in rat and its application to the follow-up of doxorubicin chemotherapy. This is a CIHR Author ManuscriptCIHR Author Manuscript CIHR Author Manuscript rapid and reliable approach to the measurement of cardiac perfusion and oxygen consumption reserve that could be applied to the development of new strategies to reduce the cardiotoxicity of anthracycline.

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Section: Pet Imagingmentioning

confidence: 99%

[11C]Acetate rest–stress protocol to assess myocardial perfusion and oxygen consumption reserve in a model of congestive heart failure in rats

Croteau¹,

Gascon²,

Bentourkia³

et al. 2012

Nuclear Medicine and Biology

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“…The LabPET initial physical performance and imaging capabilities have been investigated in previous reports (Bergeron et al 2009a) for the LabPET4 (3.75 cm axial field of view (FOV)) and LabPET8 (Prasad et al 2011) (7.5 cm axial FOV) versions. The LabPET12 (11.4 cm axial FOV) is a more recent version developed to achieve higher sensitivity and count rate performance by extending the axial FOV (Bergeron et al 2009b). Other authors have explored the advantages of large axial FOV scanners (Bao et al 2009, Huisman et al 2007, Visser et al 2009.…”

Section: Introductionmentioning

confidence: 99%

Imaging performance of LabPET APD-based digital PET scanners for pre-clinical research

et al. 2014

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The LabPET is an avalanche photodiode (APD) based digital PET scanner with quasi-individual detector read-out and highly parallel electronic architecture for high-performance in vivo molecular imaging of small animals. The scanner is based on LYSO and LGSO scintillation crystals (2×2×12/14 mm3), assembled side-by-side in phoswich pairs read out by an APD. High spatial resolution is achieved through the individual and independent read-out of an individual APD detector for recording impinging annihilation photons. The LabPET exists in three versions, LabPET4 (3.75 cm axial length), LabPET8 (7.5 cm axial length) and LabPET12 (11.4 cm axial length). This paper focuses on the systematic characterization of the three LabPET versions using two different energy window settings to implement a high-efficiency mode (250–650 keV) and a high-resolution mode (350–650 keV) in the most suitable operating conditions. Prior to measurements, a global timing alignment of the scanners and optimization of the APD operating bias have been carried out. Characteristics such as spatial resolution, absolute sensitivity, count rate performance and image quality have been thoroughly investigated following the NEMA NU 4-2008 protocol. Phantom and small animal images were acquired to assess the scanners' suitability for the most demanding imaging tasks in preclinical biomedical research. The three systems achieve the same radial FBP spatial resolution at 5 mm from the field-of-view center: 1.65/3.40 mm (FWHM/FWTM) for an energy threshold of 250 keV and 1.51/2.97 mm for an energy threshold of 350 keV. The absolute sensitivity for an energy window of 250–650 keV is 1.4%/2.6%/4.3% for LabPET4/8/12, respectively. The best count rate performance peaking at 362 kcps is achieved by the LabPET12 with an energy window of 250–650 keV and a mouse phantom (2.5 cm diameter) at an activity of 2.4 MBq ml−1. With the same phantom, the scatter fraction for all scanners is about 17% for an energy threshold of 250 keV and 10% for an energy threshold of 350 keV. The results obtained with two energy window settings confirm the relevance of high-efficiency and high-resolution operating modes to take full advantage of the imaging capabilities of the LabPET scanners for molecular imaging applications.

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“…The scanner exhibits several innovative design features rendering it as a high-resolution and highly sensitive preclinical PET scanner for small animal imaging (Tetrault et al 2008, Bergeron et al 2009a. As of today, three variants of the LabPET TM are available depending on the axial field of view (FOV), namely LabPET TM -4 (3.75 cm axial FOV), LabPET TM -8 (7.5 cm axial FOV) and LabPET TM -12 (11.4 cm axial FOV) (Bergeron et al 2009b). Following the widespread use and commercial availability of small animal PET scanners, the National Electrical Manufacturers Association (NEMA) published its NU 4-2008 standards (National Electrical Manufacturers Association 2008), a consistent and standardized methodology for measuring scanner performance parameters for small animal PET imaging.…”

Section: Introductionmentioning

confidence: 99%

NEMA NU-04-based performance characteristics of the LabPET-8™ small animal PET scanner

2011

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The objective of this study is to characterize the performance of the preclinical avalanche photodiode (APD)-based TM subsystem of the fully integrated trimodality PET/SPECT/CT Triumph TM scanner using the National Electrical Manufacturers Association (NEMA) NU 04-2008 protocol. The characterized performance parameters include the spatial resolution, sensitivity, scatter fraction, counts rate performance and image-quality characteristics. The PET system is fully digital using APD-based detector modules with highly integrated electronics. The detector assembly consists of phoswich pairs of Lu 1.9 Y 0.1 SiO 5 (LYSO) and Lu 0.4 Gd 1.6 SiO 5 (LGSO) crystals with dimensions of 2 × 2 × 14 mm 3 having 7.5 cm axial and 10 cm transverse field of view (FOV). The spatial resolution and sensitivity were measured using a small 22 Na point source at different positions in the scanner's FOV. The scatter fraction and count rate characteristics were measured using mouse-and rat-sized phantoms fitted with an 18 F line source. The overall imaging capabilities of the scanner were assessed using the NEMA image-quality phantom and laboratory animal studies. The NEMA-based radial and tangential spatial resolution ranged from 1.7 mm at the center of the FOV to 2.59 mm at a radial offset of 2.5 cm and from 1.85 mm at the center of the FOV to 1.76 mm at a radial offset of 2.5 cm, respectively. Iterative reconstruction improved the spatial resolution to 0.84 mm at the center of the FOV. The total absolute system sensitivity is 12.74% for an energy window of 250-650 keV. For the mouse-sized phantom, the peak noise equivalent count rate (NECR) is 183 kcps at 2.07 MBq cc -1 , whereas the peak true count rate is 320 kcps at 2.5 MBq cc -1 with a scatter fraction of 19%. The rat-sized phantom had a scatter fraction of 31%, with a peak NECR of 67 kcps at 0.23 MBq cc -1 and a peak true count rate of 186 kcps at 0.27 MBq cc -1 . The average activity concentration and percentage standard 4 Author to whom any correspondence should be addressed. TM system is able to produce high-quality and highly contrasted images in a reasonable time, and as such it is well suited for preclinical molecular imaging-based research.

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Performance evaluation of the LabPET12, a large axial FOV APD-based digital PET scanner

Cited by 15 publications

References 13 publications

[11C]Acetate rest–stress protocol to assess myocardial perfusion and oxygen consumption reserve in a model of congestive heart failure in rats

[11C]Acetate rest–stress protocol to assess myocardial perfusion and oxygen consumption reserve in a model of congestive heart failure in rats

Imaging performance of LabPET APD-based digital PET scanners for pre-clinical research

NEMA NU-04-based performance characteristics of the LabPET-8™ small animal PET scanner

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