Performance evaluation of the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si0001.gif" overflow="scroll"><mml:mi>Trans</mml:mi><mml:mi mathvariant="normal">-</mml:mi><mml:msup><mml:mrow><mml:mi>PET</mml:mi></mml:mrow><mml:mrow><mml:mo>®</mml:mo></mml:mrow></mml:msup><mml:mspace width="0.33em"/><mml:msup><mml:mrow><mml:mi mathvariant="normal">BioCaliburn</mml:mi></mml:mrow><mml:mrow><mml:mo>®</mml:mo></mml:mrow></mml:msup></mml:math> SH system

Zhu, J.; Wang, Luyao; Kao, Chien-Min; Kim, Heejong; Xie, Qingguo

doi:10.1016/j.nima.2014.12.086

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…The peak absolute sensitivity of the Xtrim‐PET is 2.2% for an energy window of 400–700 keV and increases up to 2.99% by increasing the width of the energy window (250–650 keV). The achieved sensitivity of the Xtrim‐PET is close to the ones achieved by scanners with longer AFOV, such as ClearPET (3.03%), rPET‐1(1%), LabPET4&8 (1.4, 2.6%), Mosaic HP (2.83%), microPET models (1.9, 2.06%), VrPET (2.22%), Trans‐PET (2.04%), microFocus220 (2.28%), RAYCAN (1.7%), Hyperion (2.6%), and the system reported by Lee et al (1.5%) . Moreover, compared to recently designed high‐resolution PET inserts, the sensitivity profile is more homogenous owing to gapless axial configuration of the Xtrim‐PET .…”

Section: Discussionsupporting

confidence: 55%

“…To ensure a fair comparison between different scanners and objectively optimize data acquisition and reconstruction protocols for a variety of applications, the National Electrical Manufacturers Association (NEMA) provided a specific standard (NEMA NU‐4) for the evaluation and performance characterization of preclinical PET scanners in terms of spatial resolution, sensitivity, scatter fraction, count rate characteristics and overall imaging performance . Subsequently, the majority of commercial small‐animal PET scanners and prototype models have been characterized according to the NEMA NU‐4 standards …”

Section: Introductionmentioning

confidence: 99%

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NEMA NU‐4 2008 performance evaluation of Xtrim‐PET: A prototype SiPM‐based preclinical scanner

et al. 2019

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Purpose: Xtrim-PET is a newly designed Silicon Photomultipliers (SiPMs)-based prototype PET scanner dedicated for small laboratory animal imaging. We present the performance evaluation of the Xtrim-PET scanner following NEMA NU-4 2008 standards to help optimizing scanning protocols which can be achieved through standard and reliable system performance characterization. Methods: The performance assessment was conducted according to the National Electrical Manufacturers Association (NEMA) NU-4 2008 standards in terms of spatial resolution, sensitivity, counting rate performance, scatter fraction and image quality. The in vivo imaging capability of the scanner is also showcased through scanning a normal mouse injected with 18 F-FDG. Furthermore, the performance characteristics of the developed scanner are compared with commercially available systems and current prototypes. Results: The volumetric spatial resolution at 5 mm radial offset from the central axis of the scanner is 6.81 µl, whereas a peak absolute sensitivity of 2.99% was achieved using a 250-650 keV energy window and a 10 ns timing window. The peak noise-equivalent count rate (NECR) using a mouselike phantom is 113.18 kcps at 0.34 KBq/cc with 12.5% scatter fraction, whereas the NECR peaked at 82.76 kcps for an activity concentration level of 0.048 KBq/cc with a scatter fraction of 25.8% for rat-like phantom. An excellent uniformity (3.8%) was obtained using NEMA image quality phantom. Recovery coefficients of 90%, 86%, 68%, 40% and 12% were calculated for rod diameters of 5, 4, 3, 2 and 1 mm, respectively. Spill-over ratios for air-filled and water-filled chambers were 35% and 25% without applying any correction for attenuation and Compton scattering effects. Conclusion: Our findings revealed that beyond compactness, lightweight, easy installation and good energy resolution, the Xtrim-PET prototype presents a reasonable performance making it suitable for preclinical molecular imaging-based research.

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