Performance evaluation of the simplified spherical harmonics approximation for cone-beam X-ray luminescence computed tomography imaging

Zhang, Haibo; Geng, Guohua; Chen, Yanrong; Zhao, Fengjun; Hou, Yi; Yi, Huangjian; Zhang, Shunli; Yu, Jingjing; He, Xiaowei

doi:10.1142/s1793545817500055

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…Cone-beam XLCT systems can also fully utilize the x-ray dose and shorten the scan time at the cost of reduced resolution. [184][185][186] The benefit of XLCT is that the excitation signal is determined by the x-ray beam, so that high-resolution molecular (optical) imaging is possible even in the presence of significant light scattering. Further, this approach might be extended to single-point detectors by scanning the radiation beam, analogous to the geometry of a confocal scanning microscope.…”

Section: Scintillation-based Molecular Imaging In Vivomentioning

confidence: 99%

Optical and x-ray technology synergies enabling diagnostic and therapeutic applications in medicine

Pogue

Wilson

2018

J. Biomed. Opt.

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X-ray and optical technologies are the two central pillars for human imaging and therapy. The strengths of x-rays are deep tissue penetration, effective cytotoxicity, and the ability to image with robust projection and computed-tomography methods. The major limitations of x-ray use are the lack of molecular specificity and the carcinogenic risk. In comparison, optical interactions with tissue are strongly scatter dominated, leading to limited tissue penetration, making imaging and therapy largely restricted to superficial or endoscopically directed tissues. However, optical photon energies are comparable with molecular energy levels, thereby providing the strength of intrinsic molecular specificity. Additionally, optical technologies are highly advanced and diversified, being ubiquitously used throughout medicine as the single largest technology sector. Both have dominant spatial localization value, achieved with optical surface scanning or x-ray internal visualization, where one often is used with the other. Therapeutic delivery can also be enhanced by their synergy, where radiooptical and optical-radio interactions can inform about dose or amplify the clinical therapeutic value. An emerging trend is the integration of nanoparticles to serve as molecular intermediates or energy transducers for imaging and therapy, requiring careful design for the interaction either by scintillation or Cherenkov light, and the nanoscale design is impacted by the choices of optical interaction mechanism. The enhancement of optical molecular sensing or sensitization of tissue using x-rays as the energy source is an important emerging field combining x-ray tissue penetration in radiation oncology with the molecular specificity and packaging of optical probes or molecular localization. The ways in which x-rays can enable optical procedures, or optics can enable x-ray procedures, provide a range of new opportunities in both diagnostic and therapeutic medicine. Taken together, these two technologies form the basis for the vast majority of diagnostics and therapeutics in use in clinical medicine.

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Section: Scintillation-based Molecular Imaging In Vivomentioning

confidence: 99%

Optical and x-ray technology synergies enabling diagnostic and therapeutic applications in medicine

Pogue

Wilson

2018

J. Biomed. Opt.

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“…In XLCT, diffusion equation (DE) is most commonly used to model the photon migration in biological tissues in the studies reported so far, and in all these studies, Eu 3+ is chosen as the luminescent particle (16,(22)(23)(24). In addition, in the research conclusions of Zhang et al, SP 3 simulation is more suitable for Eu 3+ luminescence (25).…”

Section: Introductionmentioning

confidence: 99%

A Finite Element Mesh Regrouping Strategy-Based Hybrid Light Transport Model for Enhancing the Efficiency and Accuracy of XLCT

Chu

et al. 2022

Front. Oncol.

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X-ray luminescence computed tomography (XLCT) is an emerging hybrid imaging modality in optical molecular imaging, which has attracted more attention and has been widely studied. In XLCT, the accuracy and operational efficiency of an optical transmission model play a decisive role in the rapid and accurate reconstruction of light sources. For simulation of optical transmission characteristics in XLCT, considering the limitations of the diffusion equation (DE) and the time and memory costs of simplified spherical harmonic approximation equation (SPN), a hybrid light transport model needs to be built. DE and SPN models are first-order and higher-order approximations of RTE, respectively. Due to the discontinuity of the regions using the DE and SPN models and the inconsistencies of the system matrix dimensions constructed by the two models in the solving process, the system matrix construction of a hybrid light transmission model is a problem to be solved. We provided a new finite element mesh regrouping strategy-based hybrid light transport model for XLCT. Firstly, based on the finite element mesh regrouping strategy, two separate meshes can be obtained. Thus, for DE and SPN models, the system matrixes and source weight matrixes can be calculated separately in two respective mesh systems. Meanwhile, some parallel computation strategy can be combined with finite element mesh regrouping strategy to further save the system matrix calculation time. Then, the two system matrixes with different dimensions were coupled though repeated nodes were processed according to the hybrid boundary conditions, the two meshes were combined into a regrouping mesh, and the hybrid optical transmission model was established. In addition, the proposed method can reduce the computational memory consumption than the previously proposed hybrid light transport model achieving good balance between computational accuracy and efficiency. The forward numerical simulation results showed that the proposed method had better transmission accuracy and achieved a balance between efficiency and accuracy. The reverse simulation results showed that the proposed method had superior location accuracy, morphological recovery capability, and image contrast capability in source reconstruction. In-vivo experiments verified the practicability and effectiveness of the proposed method.

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Combined multi-spectrum and orthogonal Laplacianfaces for fast CB-XLCT imaging with single-view data

Zhang

Geng

Chen

et al. 2017

Opt Rev

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Performance evaluation of the simplified spherical harmonics approximation for cone-beam X-ray luminescence computed tomography imaging

Cited by 6 publications

References 31 publications

Optical and x-ray technology synergies enabling diagnostic and therapeutic applications in medicine

Optical and x-ray technology synergies enabling diagnostic and therapeutic applications in medicine

A Finite Element Mesh Regrouping Strategy-Based Hybrid Light Transport Model for Enhancing the Efficiency and Accuracy of XLCT

Combined multi-spectrum and orthogonal Laplacianfaces for fast CB-XLCT imaging with single-view data

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