Here in this paper the power amplifier and CMOS has been explained. The present researches in sector of power amplifier and CMOS are also discussed here. The proposed work focus on the design and implementation of Class E power amplifier that should be CMOS technology based. The simulation of work is made in MATLAB. The design of circuit has been built of Simulink tool available in MATLAB. The proposed work would play significant role in designing application particular integrated circuits. Multi mode class e radio power amplifier has been using 30 nm CMOS technology with programming. This research has proposed Advanced CMOS RF Power Amplifier Architecture. Research has presented PAE% according to frequency. Comparison chart of Tradition researches where frequency was 5.2 to 13 ghz , 4 to 17 ghz, 6.5 to 13 ghz, 0.1 to 65 ghz,0.2 to 2.5 ghz in proposed research frequency 2.4ghz has been represented. Output power & power gain has been simulated in this section. Multi mode class e radio power amplifier has been using 30 nm CMOS technology with programming. Such system would be suitable for low power fifth generation wireless networks.