Performance of a first-trimester screening of preeclampsia in a routine care low-risk setting

Scazzocchio, Elena; Figueras, F.; Crispi, F.; Meler, E.; Masoller, N.; Mula, Raquel; Gratacós, Eduard

doi:10.1016/j.ajog.2012.12.016

Cited by 135 publications

(164 citation statements)

References 28 publications

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“…The most promising strategies are multiparametric approaches that include a combination of maternal factors, biophysical tests (mean blood pressure, uterine artery Doppler), and biochemical markers (44)(45)(46)(47)(48)(49)(50). Sequential multiparametric testing is superior to screening in the first trimester alone (51).…”

Section: Discussionmentioning

confidence: 99%

Dysregulated circulating miRNAs in preeclampsia

et al. 2016

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Abstract. Preeclampsia (PE) is a pregnancy-related disease with potentially severe consequences with respect to foeto-maternal morbidity and mortality. However, the molecular pathogenesis of PE remains largely unknown. Recent reports have shown that microRNAs (miRNAs or miRs) may play important roles in the development of PE. Analysing the miRNAs in sera from preeclamptic women may improve our understanding of the pathophysiological mechanisms of the disease. The aim of this retrospective study was to identify whether circulating miRNAs were differentially expressed in PE patients compared with controls. Serum samples from 23 women who developed PE were compared with samples from 44 pregnant controls. Seventeen circulating miRNAs previously described in PE were chosen for evaluation of their expression by reverse transcription quantitative polymerase chain reaction (RT-qPCR). In the maternal serum, the miR-210-3p, miR-210-5p, miR-1233-3p, and miR-574-5p levels were found to be significantly higher in the PE patients than in the controls (P<0.05). Using a logistic regression model, we evaluated the discriminant power of those differentially expressed miRNAs, and the combination of miR-210-5p and miR-574-5p yielded an area under the curve of 0.7223 for discriminating PE patients from the controls. In conclusion, the fact that four circulating miRNAs (miR-210-3p, miR-210-5p, miR-1233-3p, and miR-574-5p) were differentially expressed in the sera of women who developed PE compared with controls confirms the possible pathophysiological role of miRNAs in PE.

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Section: Discussionmentioning

confidence: 99%

Dysregulated circulating miRNAs in preeclampsia

et al. 2016

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“…Previous studies ( Table 1) have shown that combined clinical and biological markers have improved detection rates in overt PE, which could be incorporated into clinical care for early screening and assessment of patientspecific risks of PE. [29][30][31] However, the limitation of combined clinical markers and biological markers is the inability of these markers to provide definitive differentiation of the severity of PE and assessment of the PE-disease pathway. Currently, combined biomarkers of PE include cytokines, proteins, angiogenic and antiangiogenic factors that have a fundamental role in the pathogenesis and etiology of PE, as well as other related HDPs.…”

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confidence: 99%

Placenta-derived exosomes: potential biomarkers of preeclampsia

Pillay¹,

Moodley²,

Moodley³

et al. 2017

IJN

111

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Preeclampsia remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the lack of clarity on the etiology of the disorder. Although several clinical and biological markers of preeclampsia have been evaluated, they have proven to be ineffective in providing a definitive diagnosis during the various stages of the disorder. Exosomes have emerged as ideal biomarkers of pathological states, such as cancer, and have more recently gained interest in pregnancy-related complications, due to their role in cellular communication in normal and complicated pregnancies. This occurs as a result of the specific placenta-derived exosomal molecular cargo, which may be involved in normal pregnancy-associated immunological events, such as the maintenance of maternal–fetal tolerance. This review provides perspectives on placenta-derived exosomes as possible biomarkers for the diagnosis/prognosis of preeclampsia. Using keywords, online databases were searched to identify relevant publications to review the potential use of placenta-derived exosomes as biomarkers of preeclampsia.

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“…As it affects multiple organs, no single, specific and cost-effective marker to predict PE has yet been proposed [9]. However, several models have been suggested but are found to be not clinically relevant [10]- [12].…”

Section: Introductionmentioning

confidence: 99%

Changes in Platelet Indices during Pregnancy as Potential Markers for Prediction of Preeclampsia Development

Nooh¹,

Abdeldayem²

2015

OJOG

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Objective: To assess whether changes in platelet indices, detectable by simple complete blood count (CBC), during pregnancy could be used as markers for prediction of development of preeclampsia (PE). Methods: A total of 2813 pregnant women who received regular antenatal care until delivery were included. Participants were divided into 3 groups: normotensive pregnant women (n = 2621), women with PE without severe features (n = 169), and women with PE with severe features (n = 23). Blood samples were collected during antenatal visits and/or during the period of in-patient hospital stay, and changes in platelet indices were compared among the three groups. Results: Platelet count (PC) was decreasing while mean platelet volume (MPV) and platelet distribution width (PDW) were increasing as PE progressed. Receiver operating characteristics (ROC) curve analysis showed that PDW had the largest area under curve (AUC) [0.980 (95% CI: 0.964 -1.000)], making it the best marker for predicting development of PE. Also, PDW showed the most statistically significant correlation with mean arterial pressure (MAP) (r = 0.902, p = 0.000), making it the best marker for predicting severity of hypertension. Conclusion: This study provides evidence that PC decreases while MPV and PDW increase as pregnancy advances, and these changes are more pronounced in PE than normotensive pregnancy. These changes predate development of PE by 2 -8 weeks and are proportional to the progress of this disorder. The selected platelet indices, especially PDW, have the potential to be utilized as markers for not only prediction of PE development but also severity of hypertension.

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Performance of a first-trimester screening of preeclampsia in a routine care low-risk setting

Cited by 135 publications

References 28 publications

Dysregulated circulating miRNAs in preeclampsia

Dysregulated circulating miRNAs in preeclampsia

Placenta-derived exosomes: potential biomarkers of preeclampsia

Changes in Platelet Indices during Pregnancy as Potential Markers for Prediction of Preeclampsia Development

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