Performance of a Hydrogel Coated Nitinol with Oligonucleotide-Modified Nanoparticles Within Turbulent Conditions of Blood-Contacting Devices

Watson, Connor T.; Abune, Lidya; Saaid, Hicham; Wen, Connie; Wang, Y; Manning, Keefe B.

doi:10.1007/s13239-022-00650-2

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…NiTi has low toxicity, corrosion resistance, superelasticity, and biocompatibility, making them promising candidates for coatings on reconstructive surgery implants [ 13 , 14 ]. A NiTi surface coating also has a high potential for additional biomedical applications in stents, equipment and tools, staples, and dental wires [ 3 , 4 , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] ]. Passivation of the surface oxide layer on NiTi is a method to counteract the high reactivity of titanium, thereby minimizing corrosion and the release of nickel ions [ [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] ].…”

Section: Introductionmentioning

confidence: 99%

Biocompatible antibiotic-coupled nickel-titanium nanoparticles as a potential coating material for biomedical devices

McGlumphy,

Damai,

Salameh

et al. 2024

Heliyon

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Section: Introductionmentioning

confidence: 99%

Biocompatible antibiotic-coupled nickel-titanium nanoparticles as a potential coating material for biomedical devices

McGlumphy,

Damai,

Salameh

et al. 2024

Heliyon

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A review on surface modification of NiTinol for biomedical applications

Billah,

Aquib,

Dey

2024

J Mater Sci

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Elevating Postinjection Stability in Silk Nanofibril Hydrogels to Prevent Intervertebral Disc Degeneration

Liu,

Song,

Wang

et al. 2024

Biomacromolecules

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Injectable hydrogels offer a minimally invasive approach to treating intervertebral disc degeneration, a prevalent condition that affects 90% of individuals and often leads to significant pain and disability. Despite being a critical yet often overlooked issue that could lead to suboptimal therapeutic outcomes, the mechanical integrity of these gels frequently diminishes postinjection due to the injection process itself. To address this challenge, our research developed a silk-nanofibrilbased hydrogel enhanced through simple in situ polymerization of dopamine. The resulting hydrogel not only effectively preserved its modulus at over 1000 Pa postinjection, matching the mechanical properties of the nucleus pulposus, but also significantly enhanced its antioxidative properties to four times that of the original silk nanofibril-based hydrogel. Furthermore, both cell-based and animal studies substantiated that such a silk nanofibril-based hydrogel integrated with polydopamine exhibited significant therapeutic efficacy in the injectable treatment of intervertebral disc degeneration. Therefore, this work introduced a new perspective on the design of injectable hydrogels that could effectively address both the mechanical and biochemical challenges of degenerative disc diseases, providing a platform for subsequent therapeutic interventions.

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Performance of a Hydrogel Coated Nitinol with Oligonucleotide-Modified Nanoparticles Within Turbulent Conditions of Blood-Contacting Devices

Cited by 3 publications

References 37 publications

Biocompatible antibiotic-coupled nickel-titanium nanoparticles as a potential coating material for biomedical devices

Biocompatible antibiotic-coupled nickel-titanium nanoparticles as a potential coating material for biomedical devices

A review on surface modification of NiTinol for biomedical applications

Elevating Postinjection Stability in Silk Nanofibril Hydrogels to Prevent Intervertebral Disc Degeneration

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