Abstract“A Craftsman Must Sharpen His Tools to Do His Job,” said Confucius. Nuclear detection and readout techniques are the foundation of particle physics, nuclear physics, and particle astrophysics to reveal the nature of the universe. Also, they are being increasingly used in other disciplines like nuclear power generation, life sciences, environmental sciences, medical sciences, etc. The article reviews the short history, recent development, and trend of nuclear detection and readout techniques, covering Semiconductor Detector, Gaseous Detector, Scintillation Detector, Cherenkov Detector, Transition Radiation Detector, and Readout Techniques. By explaining the principle and using examples, we hope to help the interested reader underst and this research field and bring exciting information to the community.