Performance of a Rapid Whole Blood Test for <i>Helicobacter pylori</i> in Primary Care: A German Multicenter Study

Hackelsberger, Andreas; Schultze, Viola; Peitz, Ulrich; Günther, Thomas; Nilius, M.; Diete, U.; Schumacher, Michael A.; Roessner, Albert; Malfertheiner, Peter

doi:10.1046/j.1523-5378.1998.08002.x

Cited by 22 publications

(12 citation statements)

References 11 publications

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“…Assessments of other microbiology near patient tests (streptococcal throat tests,22 – 25 Helicobacter pylori ,26 – 28 and Plasmodium falciparum antigens29) were severely hampered by a lack of agreement on the standard for evaluation. For example, the three H pylori studies used the same test (Helisal Rapid Blood, Cortecs) but different reference standards.…”

Section: Resultsmentioning

confidence: 99%

Systematic review of near patient test evaluations in primary care

Delaney

Hyde

McManus

et al. 1999

BMJ

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Objective To identify and qualitatively synthesise the findings from all studies that have examined the performance and effect of near patient tests in the primary care setting. Design Systematic review of published and unpublished research 1986-99. Main outcome measures Test performance characteristics, measures of effect on clinical practice or patient outcome. Results 101 relevant publications were identified. The general quality of these papers was low, and consequently only 32 papers were assessed in detail. Although these papers gave some indication of the value of near patient testing in areas such as anticoagulation monitoring and group A haemolytic streptococcus testing, the research raised many more questions than it answered. Almost no reports were found of unbiased assessment of the effect of near patient tests in primary care on patient outcomes, organisational outcomes, or cost. Conclusions Available research provides little evidence to guide the expansion of use of near patient testing in primary care. Further research is needed in areas of clinical practice where near patient tests might be most beneficial.

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Section: Resultsmentioning

confidence: 99%

Systematic review of near patient test evaluations in primary care

Delaney

Hyde

McManus

et al. 1999

BMJ

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“…However, histological observation and the rapid urease test require endoscopy, UBT is very expensive, and serological tests require blood drawing. Recently, a rapid test using whole blood has been developed as a rapid method [15], but it has been also reported that the accuracy of the results was unreliable [16].…”

Section: Discussionmentioning

confidence: 99%

A New Rapid Test for Detecting Anti–Helicobacter pylori Antibody Excreted into Urine

et al. 2000

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“…Currently antibody detection in urine or saliva [99] are not sufficiently validated as tests for an immune response to H. pylori. This is also the case for quick tests for the antibody detection in whole blood [100,101]. Test kits to detect H. pylori-IgG-antibodies in serum should be validated for their use in Europe.…”

Section: Guideline Validity !mentioning

confidence: 99%

S3-Guideline ”Helicobacter pylori and gastroduodenal ulcer disease” of the German Society for Digestive and Metabolic Diseases (DGVS) in cooperation with the German Society for Hygiene and Microbiology, Society for Pediatric Gastroenterology and Nutrition e. V., German Society for Rheumatology, AWMF-Registration-no. 021 / 001

Fischbach

Malfertheiner²,

Hoffmann³

et al. 2009

Z Gastroenterol

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This guideline updates a prior consensus recommendation of the German Society for Digestive and Metabolic Diseases (DGVS) from 1996. It was developed by an interdisciplinary cooperation with representatives of the German Society for Hygiene and Microbiology, the Society for Pediatric Gastroenterology and Nutrition (GPGE), and the German Society for Rheumatology. The guideline is methodologically based on recommendations of the Association of the Scientific Medical Societies in Germany (AWMF) for providing a systematic evidence-based S 3 level consensus guideline and has also implemented grading criteria according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) process. Clinical applicability of study results as well as specifics for Germany in terms of epidemiology, antibiotic resistance status, diagnostics, and therapy were taken into account.

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Performance of a Rapid Whole Blood Test for Helicobacter pylori in Primary Care: A German Multicenter Study

Abstract: We found the performance of the BM test to be insufficiently accurate, as both over- and underdiagnosis of H. pylori infection were not infrequent. This test needs to be improved before its use in primary care can be recommended.

Cited by 22 publications

References 11 publications

Systematic review of near patient test evaluations in primary care

Systematic review of near patient test evaluations in primary care

A New Rapid Test for Detecting Anti–Helicobacter pylori Antibody Excreted into Urine

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