Performance of a semiautomated papanicolaou smear screening system

Abstract

In this study, PAPNET-assisted cytologic screening accurately identified smears obtained from women with high grade SIL or carcinoma. Determination of the clinical cost-effectiveness of PAPNET-assisted screening in routine practice awaits future study.

HPV DNA Testing in Cervical Cancer Screening

“…using the PAPNET (NSI, Suffern, NY) system, a semiautomated, computerassisted screening device. 22 The Thin-Prep slide was stained using a modified HPV TESTING IN CERVICAL CANCER Pap method and screened, then interpreted by a cytopathologist expert in ThinPrep cytology (M.H.). The 3 cytologic diagnoses (conventional, PAPNETassisted, and ThinPrep) were made as per the Bethesda system as within normal limits or reactive cellular changes (negative), atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion, high-grade squamous intraepithelial lesion, or carcinoma.…”

“…Cytology will likely continue to be the major screening method for cervical cancer prevention in the United States, but it has proven difficult to standardize at the highest levels of expertise. We are actively working on novel cervical cancer diagnostic assays in Costa Rica [20][21][22] and in US centers participating in an HPV testing study of management of low-grade and equivocal cytologic abnormalities. 27 In the US trial, we have seen that HPV assays such as HC II can be optimized and performed routinely at regional laboratories.…”

Can cervicography be improved? An evaluation with arbitrated cervicography interpretations

“…A. ); PapNet 4 (Neuromedical Systems, Inc, Suffern, NY [now TriPath, Elon, NC]), which uses the same slide as the Papanicolaou smear (M. E. S.); and ThinPrep 3 (M. L. H.). The Papanicolaou smear, ThinPrep, and PapNet results were classified according to the Bethesda system as negative, atypical squamous cells of undetermined significance, low-grade squamous intraepithelial lesion, high-grade squamous intraepithelial lesion, or carcinoma.…”

“…The Guanacaste site was selected because of its consistently high age-adjusted rates of cervical cancer, despite existing Papanicolaou smear screening services. 1 Visual, 2 microscopic, 3,4 and molecular 5 screening techniques are under study.…”

Histopathology and Cytopathology of Cervical Cancer

“…Such programmes have been introduced into comprehensive training and QC programmes in the USA and in the UK NHS CSP. Automated prescreening and rescreening using image analysis also may assist in standardisation [49].…”