Performance of acidified ¹⁴C‐urea capsule breath test during pantoprazole and ranitidine treatment

Abstract

The use of acidified 14C-urea capsule did not prevent false negative UBT results in patients taking pantoprazole and ranitidine, and the duration of medication does not affect the test results.

GastroPanel® Biomarker Assay: The Most Comprehensive Test for Helicobacter pylori Infection and Its Clinical Sequelae. A Critical Review

“…Because PPI drugs have antimicrobial properties, while converting the stomach into an alkaline and hostile environment for Hp growth, the bacterial load decreases, especially in the antrum, contributing easily to false-negative results of the UBT, in contrast to serology (Hp IgG or IgA antibodies), which remains unaffected in those taking PPI medication. Most of these studies in patients taking PPIs have been carried out with UBT and showed a 10-40% falsenegative rate (14,20). In addition to PPI treatment (14-16), H 2 -blockers may also give false-negative UBT results, albeit to a lesser extent than PPI medication (12,21).…”

Modified Helicobacter test using a new test meal and a 13C-urea breath test in Helicobacter pylori positive and negative dyspepsia patients on proton pump inhibitors

“…False negative results, therefore, are a limitation in the use of the standard UBT in patients on PPIs. Up to 40% of individuals taking PPIs had a false negative test result[ 5 , 6 , 19 - 22 ]. While 5 d on a PPI had no significant effect on H. pylori and the UBT, one-third of volunteers had a negative UBT after being on PPI therapy for 7 d (omeprazole 20 mg )[ 12 ].…”

Applicability of a short/rapid 13C-urea breath test for Helicobacter pylori: retrospective multicenter chart review study

“…To maintain a low gastric pH, we used high dose citric acid, which also delays gastric emptying [14]. However, others have hypothesized that these two factors appear unlikely to be the critical determinants in the increased access of urea to the urease enzyme in vivo [15-17]. …”