Abstract. Study on analysis of interaction between the upper and lower is a hot research topic at present. It is produced with the rapid development of high rise buildings and computer technology. At present, super structure and foundation are paid more attention as engineering problem. In the design of building structure, the structure of the upper column as a separate structure is fixed on the basis of this traditional method without considering the influence of interaction between superstructure and foundation and foundation. The results were different from the actual, especially in high rise buildings. The unreasonable phenomenon is more and more obvious. Use the response spectrum method analyze of the horizontal structure of seismic dynamic. Compare and summarize the different strengthening layer setting scheme, structure displacement, internal force of the earthquake response, the following related conclusion: strengthening layer can effectively reduce the horizontal displacement of the structure, and with the increased number of layer reduction will increase. The dynamic response analysis under the earthquake provides some reference and suggestions for the seismic design of this kind of structure.