Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa

Delanaye, Pierre; Vidal‐Petiot, Emmanuelle; Björk, Jonas; Ebert, Natalie; Eriksen, Bjørn Odvar; Dubourg, Laurence; Grubb, Anders; Hansson, Magnus; Littmann, K.; Mariat, Christophe; Melsom, Toralf; Schaeffner, Elke; Sundin, Per-Ola; Bökenkamp, Arend; Berg, Ulla; Åsling-Monemi, Kajsa; Åkesson, Anna; Larsson, Anders; Dalton, R. Neil; Courbebaisse, Marie; Couzi, Lionel; Garrouste, Cyril; Jacquemont, Lola; Kamar, Nassim; Legendre, Christophe; Rostaing, Lionel; Stehlé, Thomas; Haymann, Jean‐Philippe; Selistre, Luciano; Strogoff-de-Matos, Jorge Paulo; Bukabau, Justine Busanga; Sumaili, Ernest Kiswaya; Yayo, Eric; Monnet, Dagui; Nyman, Ulf; Pottel, Hans; Flamant, Martin

doi:10.1093/ndt/gfac241

Cited by 49 publications

(42 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this issue of Nephrology Dialysis Transplantation ( NDT ) two original articles are published that test the 2021 CKD-EPI equation in European settings. The first investigated how well it performs to estimate GFR in various Black and White populations [ 18 ]. The second studied the impact of using 2021 CKD-EPI equation on CKD prevalence and prognostic accuracy [ 19 ].…”

Section: What Does the Journal Add To This Discussion?mentioning

confidence: 99%

“…Delanaye et al . studied on behalf of the European Kidney Function Consortium (EKFC) the accuracy of the 2009 and 2021 CKD-EPI equations, as well as the accuracy of a GFR estimation equation that this consortium previously developed, the EKFC equation [ 18 , 20 ]. This equation uses sex-, age- and race-specific median creatinine values obtained from healthy subjects to mathematically estimate GFR from a given serum creatinine value [ 20 ].…”

Section: What Does the Journal Add To This Discussion?mentioning

confidence: 99%

“…The authors found that in European Whites the accuracy of the 2021 CKD-EPI equation was lower than in non-Blacks in the publication by CKD-EPI. In fact, of the three equations tested, the accuracy of the 2021 CKD-EPI equation was the lowest, with an overestimation of mGFR by 6.0 mL/min/1.73 m 2 , followed by an overestimation by 3.0 mL/min/1.73 m 2 by the 2009 CKD-EPI equation [ 18 ]. The best performance was noted for the EKFC equation, with a slight underestimation of 0.3 mL/min/1.73 m 2 [ 18 ].…”

Section: What Does the Journal Add To This Discussion?mentioning

confidence: 99%

“…In fact, of the three equations tested, the accuracy of the 2021 CKD-EPI equation was the lowest, with an overestimation of mGFR by 6.0 mL/min/1.73 m 2 , followed by an overestimation by 3.0 mL/min/1.73 m 2 by the 2009 CKD-EPI equation [ 18 ]. The best performance was noted for the EKFC equation, with a slight underestimation of 0.3 mL/min/1.73 m 2 [ 18 ]. The authors offer several explanations for why the 2021 CKD-EPI equation performs less well in their study.…”

Section: What Does the Journal Add To This Discussion?mentioning

confidence: 99%

“…The validation results by the EKFC are promising. Performance in terms of bias and accuracy seems better [ 18 , 20 ], but external validation is needed, preferably by independent research groups using large datasets including populations from outside Europe. An advantage could also be that this equation can be used for all age groups, and not only for adults, as holds for the CKD-EPI equation (Table 1 ).…”

Section: How To Move Forward?mentioning

confidence: 99%

See 4 more Smart Citations

What should European nephrology do with the new CKD-EPI equation?

Gansevoort

Anders

Cozzolino

et al. 2022

Nephrology Dialysis Transplantation

View full text Add to dashboard Cite

Section: What Does the Journal Add To This Discussion?mentioning

confidence: 99%

Section: What Does the Journal Add To This Discussion?mentioning

confidence: 99%

Section: What Does the Journal Add To This Discussion?mentioning

confidence: 99%

Section: What Does the Journal Add To This Discussion?mentioning

confidence: 99%

Section: How To Move Forward?mentioning

confidence: 99%

See 3 more Smart Citations

What should European nephrology do with the new CKD-EPI equation?

Gansevoort

Anders

Cozzolino

et al. 2022

Nephrology Dialysis Transplantation

View full text Add to dashboard Cite

Assessment of Cystatin C Level for Risk Stratification in Adults With Chronic Kidney Disease

et al. 2022

Self Cite

View full text Add to dashboard Cite

ImportanceKidney function is usually estimated from serum creatinine level, whereas an alternative glomerular filtration marker (cystatin C level) associates more closely with future risk of cardiovascular disease (CVD) and mortality.ObjectivesTo evaluate whether testing concordance between estimated glomerular filtration rates based on cystatin C (eGFRcys) and creatinine (eGFRcr) levels would improve risk stratification for future outcomes and whether estimations differ by age.Design, Setting, and ParticipantsA prospective population-based cohort study (UK Biobank), with participants recruited between 2006-2010 with median follow-up of 11.5 (IQR, 10.8-12.2) years; data were collected until August 31, 2020. Participants had eGFRcr greater than or equal to 45 mL/min/1.73 m2, albuminuria (albumin &lt;30 mg/g), and no preexisting CVD or kidney failure.ExposuresChronic kidney disease status was categorized by concordance between eGFRcr and eGFRcys across the threshold for hronic kidney disease (CKD) diagnosis (60 mL/min/1.73 m2).Main Outcomes and MeasuresTen-year probabilities of CVD, mortality, and kidney failure were assessed according to CKD status. Multivariable-adjusted Cox proportional hazards models tested associations between CVD and mortality. Area under the receiving operating curve tested discrimination of eGFRcr and eGFRcys for CVD and mortality. The Net Reclassification Index assessed the usefulness of eGFRcr and eGFRcys for CVD risk stratification. Analyses were stratified by older (age 65-73 years) and younger (age &lt;65 years) age.ResultsThere were 428 402 participants: median age was 57 (IQR, 50-63) years and 237 173 (55.4%) were women. Among 76 629 older participants, there were 9335 deaths and 5205 CVD events. Among 351 773 younger participants, there were 14 776 deaths and 9328 CVD events. The 10-year probability of kidney failure was less than 0.1%. Regardless of the eGFRcr, the 10-year probabilities of CVD and mortality were low when eGFRcys was greater than or equal to 60 mL/min/1.73 m2; conversely, with eGFRcys less than 60 mL/min/1.73 m2, 10-year risks were nearly doubled in older adults and more than doubled in younger adults. Use of eGFRcys better discriminated CVD and mortality risk than eGFRcr. Across a 7.5% 10-year risk threshold for CVD, eGFRcys improved case Net Reclassification Index by 0.7% (95% CI, 0.6%-0.8%) in older people and 0.7% (95% CI, 0.7%-0.8%) in younger people; eGFRcr did not add to CVD risk estimation.Conclusions and RelevanceThe findings of this study suggest that eGFRcr 45 to 59 mL/min/1.73 m2 includes a proportion of individuals at low risk and fails to capture a substantial proportion of individuals at high-risk for CVD and mortality. The eGFRcys appears to be more sensitive and specific for CVD and mortality risks in mild CKD.

show abstract

Neue Formeln zur Schätzung der Nierenfunktion – Bedeutung für die Dosierung nierengängiger Arzneimittel

Ebert

2024

Innere Medizin

View full text Add to dashboard Cite

Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa

Cited by 49 publications

References 36 publications

What should European nephrology do with the new CKD-EPI equation?

What should European nephrology do with the new CKD-EPI equation?

Assessment of Cystatin C Level for Risk Stratification in Adults With Chronic Kidney Disease

Neue Formeln zur Schätzung der Nierenfunktion – Bedeutung für die Dosierung nierengängiger Arzneimittel

Contact Info

Product

Resources

About