Performance of different add-on devices in dual limb non-invasive mechanically ventilated circuit

Rashad, Amal; Mohammad, Mohammad F; Eckes, Myriam; Porée, Thierry; Sarhan, Rania M.; Madney, Yasmin M.; Abdelrahim, Mohamed

doi:10.1016/j.jddst.2021.102897

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…The only difference was that they discovered a higher oxygen flow than we did. That could be due to their use of a higher tidal volume (750 mL), which is 250 mL higher than the normal tidal volume used in most in vitro studies (500 mL) but more realistic for some adult patients [22][23][24][25][26][27][28][29][30][31][32][33], as well as their use of a valved facemask only, for which we found the best oxygen flow was 3 L/min [21], implying that the higher tidal flow improved the benefit of oxygen delivered as a supplement to the aerosol within the HC.…”

Section: Discussionmentioning

confidence: 99%

Effect of oxygen flow on aerosol delivery from a vibrating mesh nebulizer with a holding chamber

Amin

Taha

Hussein

et al. 2022

Beni-Suef Univ J Basic Appl Sci

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Background A holding chamber (HC) was created to work with a vibrating mesh nebulizer (VMN) to boost the total inhalable dose for patients. In addition to the optional supply of supplemental oxygen, it facilitates intermittent and continuous nebulization. Our goal was to see how well a VMN coupled to a HC with a mouthpiece or valved facemask performed at varied oxygen flows starting at 0–6 L/min. In this study, we used a breathing simulator to simulate adults' spontaneous breathing patterns with a tidal volume of 500 mL and a 1:1 inhalation–exhalation ratio. For the combination of nebulizer and HC adapter with a valved facemask or mouthpiece, five determinations were made. Salbutamol was recovered and evaluated using high-performance liquid chromatography from the inhalation filter connected to the breathing simulator, the nebulizer reservoir chamber, and the HC. Results The amount of salbutamol in the nebulizer reservoir chamber and within the HC did not differ significantly when using a mouthpiece or a valved facemask. However, the supplied dose to the inhalation filter was increased until oxygen flow reached 2 and 3 L/min using the mouthpiece and valved facemask as interfaces, respectively. The supplied salbutamol was much higher at this flow than at the other oxygen flows. This was followed by a progressive reduction in the supplied salbutamol until the lowest given dose was reached at 6 L/min oxygen flow, p < 0.005. Conclusions The supplied doses of salbutamol to the inhalation filter were variable with the VMN connected to the HC and mouthpiece or valved facemask, with significant improvements until an oxygen flow of 2 L/min with a mouthpiece and 3 L/min with a valved facemask, followed by gradual decreases to lower values at an oxygen flow of 6 L/min. An in vivo investigation is required to further validate the findings.

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