Performance of electrospun nanofibers for SPE of drugs from aqueous solutions

Abstract

A novel extraction technique was reported. The solid phase material, nanofiber, was prepared by electrospinning using polystyrene. Twenty different drugs (10 microg/L in water) were extracted using 1 mg of nanofibers within 5 min. The analytes can be desorpted from the fibers with 50 microL of the methanol and then monitored by LC coupled to a UV detector. Packed-fiber SPE (PFSPE) provide high recoveries (>50%) for some relatively non-polar drugs (log P >1.5) (n-octanol-to-water partition ratio), and relatively low recoveries (9.9-39.8%) for the drugs within the log P window below 1. Experimental optimization of the technique has been carried out using seven representative drugs, edaravone, cinchonine, quinine, voriconazole, chlordiazepoxide, verapamil, and rutonding. Except for edaravone, the maximum yields of seven drugs (0.2 microg/L) from water samples were approximately 100%, and were 33.7-88.2% from human plasma. The advantageous aspect of the technique encompasses high throughput, high sensitivity, simplicity, low cost, and green chemistry.

Electrospun polystyrene/Aliquat 336 for preconcentration and determination of thiocyanate in flow analysis

“…Each column was conditioned by passing 1 M sodium nitrate solution for 10 min to convert Aliquat 336 from its chloride form to its nitrate form, and then deionized water was passed for 50 min to remove any excess Aliquat 336. [29,34,35]. The usability of DMF/THF mixtures as the solvents for the electrospinning solution containing PS and Aliquat 336 was tested.…”

“…A series of studies have been conducted by Kang et al on the use of electrospun polystyrene fibres as a material for solid phase extraction of organic molecules [15,[28][29][30][31][32]. They prepared fibre-packed solid phase extraction columns by inserting segments of electrospun polystyrene fibre mat into pippette tips and pressing it down.…”

Electrospun nanofiber sorbents for the pre-concentration of urinary 1-hydroxypyrene

“…Their high specific surface areas (Liu et al 2010;Aguado et al 2009;Zhang et al 2008) and ease of functionalization with various groups for specific purposes (Kang et al 2007;Kang et al 2008;Yoshitake et al 2003) has increased their acceptance in the scientific community. The simplest and most flexible means of fabricating nanofibers is via electrospinning (Chigome et al 2011;Uyar and Besenbacher 2008;Greiner and Wendorff 2007;Ramakrishna et al 2006).…”

Detection of Phthalate Esters in Environmental Water Samples –Comparison of Nylon6 Nanofibers Mat‐based Solid Phase Extraction and Other Conventional Extraction Methods

“…15 Kang et al [16][17][18] packed polystyrene nanofibers tightly into a tip as SPE columns, but only small volume samples (2 mL) were handled because of the existence of high column pressure. In fact, electrospun nanofibers were usually obtained as a form of membrane or so-called "mat".…”